Ignet

Gene Information

Gene symbol: DAB2

Gene name: disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

HGNC ID: 2662

Synonyms: DOC-2

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	ALMS1	1 hits
3	ANGPT2	1 hits
4	APOL1	1 hits
5	BCAS3	1 hits
6	CALR	1 hits
7	CPS1	1 hits
8	FCGRT	1 hits
9	GCKR	1 hits
10	LASS2	1 hits
11	LRP2	1 hits
12	MYH9	1 hits
13	PIP5K1B	1 hits
14	PRKAG2	1 hits
15	RAB38	1 hits
16	SHROOM3	1 hits
17	SLC22A2	1 hits
18	SLC34A1	1 hits
19	SLC6A13	1 hits
20	SLC7A7	1 hits
21	SLC7A9	1 hits
22	TFDP2	1 hits
23	TMEM60	1 hits
24	UBE2Q2	1 hits
25	UMOD	1 hits
26	VEGFA	1 hits
27	WDR37	1 hits
28	WDR72	1 hits

Related Sentences

#	PMID	Sentence
1	20383146	Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
2	26054544	In a second model, loss of endogenous albumin was induced in rats by podocyte-specific transgenic expression of diphtheria toxin receptor.
3	26054544	Analysis of known albumin receptors and assessment of cortical protein expression in the albumin overload model, conducted to identify potential proteins and pathways affected by acute protein overload, revealed changes in the expression levels of calreticulin, disabled homolog 2, NRF2, angiopoietin-2, and proteins involved in ATP synthesis.
4	32736701	Megalin-mediated albumin endocytosis in cultured murine mesangial cells.
5	32736701	Some of this function has been attributed to the megalin/cubilin (Lrp2/Cubn) receptor complex and the albumin recycling protein FcRn (Fcgrt).
6	32736701	Here, the expression of megalin and FcRn in murine mesangial cells along with the megalin adaptor protein Dab-2 (Dab2) was shown for the first time.
7	32736701	Cubilin mRNA expression was detected, but the absence of the cubilin partner amnionless (Amn) suggested that cubilin is minimally functional, if at all, in these cells.
8	32736701	Albumin endocytosis was significantly impaired (p < 0.01) under inducible megalin knockdown conditions in stably transduced mesangial cells.
9	32736701	The current work provides both the novel identification of megalin and FcRn in mesangial cells and the functional demonstration of megalin-mediated albumin endocytosis.
10	33377622	Genome-wide association studies have implicated genetic variants in UMOD, MYH9, APOL-1, SHROOM3, RAB38, and DAB2 have a higher risk for ESRD in hypertensive patients.