- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: DIABLO
Gene name: diablo, IAP-binding mitochondrial protein
HGNC ID: 21528
Synonyms: SMAC, DIABLO-S, FLJ25049, FLJ10537, DFNA64
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYCS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 30765684 | Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis. |
| 2 | 30765684 | BACKGROUND PGC-1α can be activated by deacetylation reactions catalyzed by SIRT1. |
| 3 | 30765684 | However, it is unknown whether the renal-protective effect of resveratrol is further related to activation of the podocyte SIRT1/PGC-1α pathway. |
| 4 | 30765684 | The protein and mRNA expression levels of SIRT1, PGC-1α, NRF1, and TFAM were detect by immunofluorescence, Western blot analysis, and qRT-PCR in the podocytes, respectively. |
| 5 | 30765684 | RESULTS We found that high-glucose stimulation results in time-dependent decreases in the expression of SIRT1, PGC-1α, and its downstream genes NRF1 and mitochondrial transcription factor A (TFAM) for mouse podocytes, and increases ROS levels in cells and mitochondria. |
| 6 | 30765684 | In addition, it can also reduce the release of mitochondrial cytochrome C and DIABLO proteins to the cytoplasm and increase respiratory chain complex I and III activity and mitochondrial membrane potential. |
| 7 | 30765684 | CONCLUSIONS Resveratrol can reduce the oxidative damage and apoptosis of podocytes induced by high-glucose stimulation via SIRT1/PGC-1α-mediated mitochondrial protection. |