Ignet

Gene Information

Gene symbol: DIAPH1

Gene name: diaphanous homolog 1 (Drosophila)

HGNC ID: 2876

Synonyms: hDIA1, LFHL1

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CD36	1 hits
3	DIAPH2	1 hits
4	DIAPH3	1 hits
5	FMN1	1 hits
6	GAS1	1 hits
7	INF2	1 hits
8	IQGAP1	1 hits
9	NES	1 hits

Related Sentences

#	PMID	Sentence
1	21258034	The recent identification of mutations in the INF2 gene, which encodes a member of the formin family of actin-regulating proteins, in cases of familial FSGS supports the importance of an intact actin cytoskeleton in podocyte function.
2	21258034	Six of the seven distinct altered residues localized to an INF2 region that corresponded to a subdomain of the mDia1 diaphanous inhibitory domain reported to co-immunoprecipitate with IQ motif-containing GTPase-activating protein 1 (IQGAP1).
3	21258034	Because IQGAP1 interacts with crucial podocyte proteins such as nephrin and PLCε1, the identification of mutations that may alter the putative INF2-IQGAP1 interaction provides additional insight into the pathophysiologic mechanisms linking formin proteins to podocyte dysfunction and FSGS.
4	21278336	Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).
5	21278336	In a yeast two-hybrid screen, we identified the diaphanous autoregulatory domains (DADs) of the mammalian diaphanous-related formins (mDias) mDia1, mDia2, and mDia 3 as INF2_DID-interacting partners.
6	21278336	We investigated the influence of this INF2_DID/mDia_DAD interaction on mDia mediated actin polymerization and on serum response factor (SRF) activation.
7	21278336	We find that the interaction of INF2_DID with mDia_DAD inhibited mDia-mediated, Rho-activated actin polymerization, as well as SRF-responsive gene transcriptional changes.
8	30132346	Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.
9	30132346	Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction.
10	30132346	After 6 mo of hyperglycemia, diabetic Diaph1^-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.
11	30132346	In glomerular isolates, expression of two genes linked to podocyte stress, growth arrest-specific 1 ( Gas1) and cluster of differentiation 36 ( Cd36), was significantly attenuated in diabetic Diaph1^-/- mice compared with controls, in parallel with significantly higher levels of nestin (Nes) mRNA, a podocyte marker.
12	30132346	Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.
13	30132346	Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction.
14	30132346	After 6 mo of hyperglycemia, diabetic Diaph1^-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.
15	30132346	In glomerular isolates, expression of two genes linked to podocyte stress, growth arrest-specific 1 ( Gas1) and cluster of differentiation 36 ( Cd36), was significantly attenuated in diabetic Diaph1^-/- mice compared with controls, in parallel with significantly higher levels of nestin (Nes) mRNA, a podocyte marker.
16	30132346	Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.
17	30132346	Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction.
18	30132346	After 6 mo of hyperglycemia, diabetic Diaph1^-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.
19	30132346	In glomerular isolates, expression of two genes linked to podocyte stress, growth arrest-specific 1 ( Gas1) and cluster of differentiation 36 ( Cd36), was significantly attenuated in diabetic Diaph1^-/- mice compared with controls, in parallel with significantly higher levels of nestin (Nes) mRNA, a podocyte marker.
20	30132346	Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.
21	30132346	Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction.
22	30132346	After 6 mo of hyperglycemia, diabetic Diaph1^-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.
23	30132346	In glomerular isolates, expression of two genes linked to podocyte stress, growth arrest-specific 1 ( Gas1) and cluster of differentiation 36 ( Cd36), was significantly attenuated in diabetic Diaph1^-/- mice compared with controls, in parallel with significantly higher levels of nestin (Nes) mRNA, a podocyte marker.