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Gene Information

Gene symbol: DNAJA2

Gene name: DnaJ (Hsp40) homolog, subfamily A, member 2

HGNC ID: 14884

Synonyms: HIRIP4, DNAJ, CPR3, DNJ3

Related Genes

#	Gene Symbol	Number of hits
1	HSPA1A	1 hits
2	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	9553041	Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
2	9553041	By immunoprecipitation and protein microsequencing analysis, we have identified a major cellular protein associated with endogenous WT1 to be the inducible chaperone Hsp70.
3	9553041	WT1 and Hsp70 are physically associated in embryonic rat kidney cells, in primary Wilms tumor specimens and in cultured cells with inducible expression of WT1.
4	9553041	Colocalization of WT1 and Hsp70 is evident within podocytes of the developing kidney, and Hsp70 is recruited to the characteristic subnuclear clusters that contain WT1.
5	9553041	The amino-terminal transactivation domain of WT1 is required for binding to Hsp70, and expression of that domain itself is sufficient to induce expression of Hsp70 through the heat shock element (HSE).
6	9553041	Substitution of a heterologous Hsp70-binding domain derived from human DNAJ is sufficient to restore the functional properties of a WT1 protein with an amino-terminal deletion, an effect that is abrogated by a point mutation in DNAJ that reduces binding to Hsp70.
7	9553041	These observations indicate that Hsp70 is an important cofactor for the function of WT1, and suggest a potential role for this chaperone during kidney differentiation.