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Gene Information
Gene symbol: DNM1
Gene name: dynamin 1
HGNC ID: 2972
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DNM2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23187129 | Here we used a conditional double-KO of dynamin 1 (Dnm1) and Dnm2 in mouse podocytes to confirm dynamin's role in podocyte foot process maintenance. |
| 2 | 23187129 | In addition, we demonstrated that while synaptojanin 1 (Synj1) KO mice and endophilin 1 (Sh3gl2), endophilin 2 (Sh3gl1), and endophilin 3 (Sh3gl3) triple-KO mice had grossly normal embryonic development, these mutants failed to establish a normal filtration barrier and exhibited severe proteinuria due to abnormal podocyte foot process formation. |
| 3 | 30350425 | Specifically, dynamin regulates the actin cytoskeleton and the turnover of nephrin in podocytes, and knocking down dynamin expression causes proteinuria. |
| 4 | 30350425 | We found that glomerular Dnm2 and Dnm1 mRNA levels are increased prior to the onset of proteinuria in a rat model of spontaneous proteinuria. |
| 5 | 30350425 | Finally, we show that the glomerular expression of dynamin and cathepsin L protein is increased in several human proteinuric kidney diseases. |