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Gene Information

Gene symbol: DUSP5

Gene name: dual specificity phosphatase 5

HGNC ID: 3071

Synonyms: HVH3

Related Genes

#	Gene Symbol	Number of hits
1	DUSP26	1 hits
2	MAPK1	1 hits

Related Sentences

#	PMID	Sentence
1	30862678	Dual specificity phosphatases (DUSPs) are a family of phosphatases mainly responsible for MAPK inhibition.
2	30862678	Diabetes-induced DUSP4 reduction enhanced p38 and c-Jun N-terminal kinase (JNK) activity and podocyte dysfunction.
3	30862678	The overexpression of DUSP4 prevented the activation of p38, JNK, caspase 3/7 activity, and NADPH oxidase 4 expression induced by high glucose level exposure.
4	30862678	These morphological changes were associated with profound podocyte foot process effacement, cell death, and sustained p38 and JNK activation.
5	30862678	Moreover, inhibition of protein kinase C-δ prevented DUSP4 expression decline and p38/JNK activation in the podocytes and renal cortex of diabetic mice.
6	31155289	Dual-specificity phosphatase 26 (DUSP26) is a member of the Dusp protein family, and is suggested to be involved in divers biological and pathological processes, such as cell growth, differentiation, inflammation and apoptosis.
7	31155289	DUSP26 deficiency accelerated renal injury and dysfunction, as evidenced by the elevated glomerulosclerosis, reduced expression of Nephrin and promoted glomerular basement membrane thickness.
8	31155289	Moreover, STZ-induced fibrosis in kidney glomeruli of DN mice was markedly prolonged in DUSP26-knockout mice through potentiating transforming growth factor-β1 (TGF-β1) expression.
9	31155289	More importantly, reducing ROS generation could significantly abolish DUSP26 knockdown-exacerbated TGF-β1 expression and MAPKs activation, thereby protecting podocytes from GLU-induced podocyte injury.