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Gene Information
Gene symbol: EIF2AK3
Gene name: eukaryotic translation initiation factor 2-alpha kinase 3
HGNC ID: 3255
Synonyms: PEK, PERK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF6 | 1 hits |
| 2 | CASP12 | 1 hits |
| 3 | ERN1 | 1 hits |
| 4 | FUS | 1 hits |
| 5 | IQGAP1 | 1 hits |
| 6 | NOX5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26197866 | AOPP treatment induced overexpression of glucose-regulated protein 78 and CCAAT/enhancer-binding protein-homologous protein (CHOP) in podocytes, indicating that AOPPs induced ER stress. |
| 2 | 26197866 | Moreover, silencing of the three ER stress sensors, protein kinase-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol requiring 1 (IRE1), respectively, significantly lowered the apoptotic rate of the cells compared with that of the scramble siRNA-transfected cells. |
| 3 | 26197866 | Lastly, our data suggested that CHOP- and caspase-12-dependent pathways were involved in ER stress-mediated podocyte apoptosis and that Bcl-2 suppression was involved in CHOP-mediated apoptosis. |
| 4 | 26197866 | Collectively, our results indicate for the first time that AOPPs trigger podocyte apoptosis through induction of ER stress, which might be regulated by NADPH oxidase-dependent ROS through RAGE, and that this apoptosis is mediated by three unfolded protein response pathways, the PERK, ATF6, and IRE1 pathways, and the mediators, CHOP and caspase-12. |
| 5 | 27377965 | In contrast to IQGAP1, IQGAP2 expression remained cytoplasmic. |
| 6 | 27377965 | IQGAP1 nuclear translocation was associated with a significant decrease in its interaction with nephrin and podocalyxin. |
| 7 | 27377965 | The interaction between IQGAP1 and P-ERK increased upon podocyte exposure to PAN. |
| 8 | 34988075 | Mitofusin2 (Mfn2) was initially identified as a dynamin-like protein involved in fusing the outer mitochondrial membrane (OMM). |
| 9 | 34988075 | Streptozotocin (STZ)-induced diabetic rats exhibited abnormal mitochondrial morphology and MAMs reduction in podocytes, accompanied by decreased expression of Mfn2 and activation of all three unfolded protein response (UPR) pathways (IRE1, ATF6, and PERK). |