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Gene Information
Gene symbol: EIF4EBP1
Gene name: eukaryotic translation initiation factor 4E binding protein 1
HGNC ID: 3288
Synonyms: PHAS-I, 4E-BP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRTC1 | 1 hits |
| 2 | MKI67 | 1 hits |
| 3 | NPHS2 | 1 hits |
| 4 | PCNA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22773827 | We generated transgenic Fischer 344 rats that express a dominant negative AA-4E-BP1 transgene driven by the podocin promoter; a member of the mammalian target of rapamycin complex 1 (mTORC1) pathway, 4E-BP1 modulates cap-dependent translation, which is a key determinant of a cell's hypertrophic response to nutrients and growth factors. |
| 2 | 30858353 | Importantly, targeting 4E-BP1 activation by the RNA interference of 4E-BP1 or pharmacologic rapamycin (inhibitor of mTORC1, blocking mTORC1-dependent phosphorylation of its substrate 4E-BP1) treatment was able to inhibit the increases of PCNA, Ki67, and the S-phase fraction of cell cycle in primary podocyte during 2-6 h of adriamycin treatment, and also attenuated the following apoptotic cell death of podocyte detected from the 4th hour, suggesting that 4E-BP1 could be a regulator to manipulate the amount of cell cycle re-entry provided by differentiated podocyte, and thus regulate the degree of podocyte apoptosis, bringing us a new potential podocyte-protective substance that can be used for therapy. |