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Gene Information
Gene symbol: FGF4
Gene name: fibroblast growth factor 4
HGNC ID: 3682
Synonyms: K-FGF, HBGF-4, HST, HST-1, KFGF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD2AP | 1 hits |
| 2 | CD44 | 1 hits |
| 3 | EGF | 1 hits |
| 4 | HGF | 1 hits |
| 5 | ITGAV | 1 hits |
| 6 | ITGB1 | 1 hits |
| 7 | NPHS1 | 1 hits |
| 8 | NPHS2 | 1 hits |
| 9 | PDGFB | 1 hits |
| 10 | SH3KBP1 | 1 hits |
| 11 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20031026 | This study demonstrates that the expression of the mesenchymal markers CD29 and CD44, the epithelial markers CD51 and ZO-1 and the podocyte markers CD2AP and NPHS2 can be induced in these cells via incubation with epidermal growth factor/platelet-derived growth factor BB and fibroblast growth factor 4/hepatocyte growth factor, respectively. |
| 2 | 20457601 | CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. |
| 3 | 20457601 | Podocyte damage is the basis of many glomerular diseases with ultrastructural changes and decreased expression of components of the slit diaphragm such as nephrin and podocin. |
| 4 | 20457601 | In this manuscript we examined a mechanism of nephrin endocytosis via CIN85/Ruk(L)-mediated ubiquitination. |
| 5 | 20457601 | We can demonstrate that the loss of nephrin expression and onset of the proteinuria in CD2AP(-/-) mice correlates with an increased accumulation of ubiquitinated proteins and expression of CIN85/Ruk(L) in podocytes. |
| 6 | 20457601 | In cultured murine podocytes CD2AP deficiency leads to an early ubiquitination of nephrin and podocin after stimulation with fibroblast growth factor-4. |
| 7 | 20457601 | Binding assays with different CIN85/Ruk isoforms and mutants showed that nephrin and podocin are binding to the coiled-coil domain of CIN85/Ruk(L). |
| 8 | 20457601 | We found that in the presence of CIN85/Ruk(L), which is involved in down-regulation of receptor-tyrosine kinases, nephrin is internalized after stimulation with fibroblast growth factor-4. |
| 9 | 20457601 | Interestingly, coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L). |
| 10 | 20457601 | CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. |
| 11 | 20457601 | Podocyte damage is the basis of many glomerular diseases with ultrastructural changes and decreased expression of components of the slit diaphragm such as nephrin and podocin. |
| 12 | 20457601 | In this manuscript we examined a mechanism of nephrin endocytosis via CIN85/Ruk(L)-mediated ubiquitination. |
| 13 | 20457601 | We can demonstrate that the loss of nephrin expression and onset of the proteinuria in CD2AP(-/-) mice correlates with an increased accumulation of ubiquitinated proteins and expression of CIN85/Ruk(L) in podocytes. |
| 14 | 20457601 | In cultured murine podocytes CD2AP deficiency leads to an early ubiquitination of nephrin and podocin after stimulation with fibroblast growth factor-4. |
| 15 | 20457601 | Binding assays with different CIN85/Ruk isoforms and mutants showed that nephrin and podocin are binding to the coiled-coil domain of CIN85/Ruk(L). |
| 16 | 20457601 | We found that in the presence of CIN85/Ruk(L), which is involved in down-regulation of receptor-tyrosine kinases, nephrin is internalized after stimulation with fibroblast growth factor-4. |
| 17 | 20457601 | Interestingly, coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L). |