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Gene Information
Gene symbol: FIGF
Gene name: c-fos induced growth factor (vascular endothelial growth factor D)
HGNC ID: 3708
Synonyms: VEGF-D
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FLT4 | 1 hits |
| 2 | VEGFA | 1 hits |
| 3 | VEGFC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16209358 | Two members of the VEGF family, VEGF-C and VEGF-D are lymphangiogenic when activate VEGFR-3. |
| 2 | 16209358 | Finally, podoplanin is a glomerular podocyte membrane mucoprotein, which occurs together with VEGFR-3 in the lymphatic endothelium. |
| 3 | 16525158 | Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3. |
| 4 | 16525158 | As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 dependent. |
| 5 | 16525158 | VEGF-C protein expression was localized to podocytes in contrast to VEGF-D, which was expressed in parietal epithelial cells. |
| 6 | 16525158 | Cytotoxicity experiments revealed that in hCIPs VEGF-C reduced cytotoxicity to 81.4+/-1.9% of serum-starved conditions (P<0.001, paired t-test, n=16), similar to VEGF-A (82.8+/-4.5% of serum-starved conditions, P<0.05, paired t-test). |
| 7 | 16525158 | VEGF-C was also shown to induce a 0.5+/-0.13-fold reduction in levels of MAPK phosphorylation compared with VEGF-A and VEGF-A-Mab treatment (P<0.05, ANOVA, n=4), yet had no effect on Akt phosphorylation. |