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Gene Information
Gene symbol: FKBP4
Gene name: FK506 binding protein 4, 59kDa
HGNC ID: 3720
Synonyms: FKBP59, FKBP52
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FKBP11 | 1 hits |
| 2 | FKBP5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20630936 | Here, we show that cultured murine podocytes express key components of the GR complex, including the GR, heat shock protein 90, and the immunophilins FKBP51 and FKBP52. |
| 2 | 32664235 | Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes. |
| 3 | 32664235 | Primary membranous nephropathy is usually caused by antibodies against the podocyte antigen membrane M-type phospholipase A2 receptor (PLA2R). |
| 4 | 32664235 | We have now identified key TNF receptor superfamily members in podocytes and explored the regulation of PLA2R expression and the impact of tacrolimus. |
| 5 | 32664235 | Data mining of single cell transcriptomics and glomerular transcriptomics data identified TNFRSF12a/Fn14 as the highest expressed TNF receptor superfamily gene in human membranous nephropathy, and this was confirmed by immunohistochemistry that also identified NFκB activation in membranous nephropathy podocytes. |
| 6 | 32664235 | Furthermore, in cultured human podocytes, TWEAK increased the expression of PLA2R as well as the expression of other genes recently identified by GWAS as linked to membranous nephropathy: NFKB1 and IRF4. |
| 7 | 32664235 | Interestingly, IRF4 encodes the FK506-binding protein 52 (FKBP52), a protein associated with tacrolimus. |
| 8 | 32664235 | Tacrolimus prevented the increased expression of PLA2R, NFKB1 and IRF4 induced by TWEAK in cultured podocytes. |