Ignet

Gene Information

Gene symbol: FLT4

Gene name: fms-related tyrosine kinase 4

HGNC ID: 3767

Synonyms: VEGFR3, PCL

Related Genes

#	Gene Symbol	Number of hits
1	AGTRL1	1 hits
2	APLN	1 hits
3	CCL16	1 hits
4	CDH5	1 hits
5	FIGF	1 hits
6	FLT1	1 hits
7	FOXC2	1 hits
8	KDR	1 hits
9	LYVE1	1 hits
10	MYH14	1 hits
11	MYL2	1 hits
12	PDPN	1 hits
13	PECAM1	1 hits
14	PROX1	1 hits
15	TEK	1 hits
16	VEGFA	1 hits
17	VEGFC	1 hits

Related Sentences

#	PMID	Sentence
1	10027397	In normal skin and kidney, podoplanin colocalized with vascular endothelial growth factor receptor-3, the only other lymphatic marker presently available.
2	10027397	Complementary immunostaining of blood vessels was obtained with established endothelial markers (CD31, CD34, factor VIII-related antigen, and Ulex europaeus I lectin) as well as podocalyxin, another podocytic protein that is also localized in endothelia of blood vessels.
3	15465483	We have conducted a study of Foxc2 expression during mouse development using immunohistochemistry, and examined its expression in lymphatics compared to its paralog Foxc1 and to Vegfr-3, Prox1 and other lymphatic and blood vascular proteins.
4	16209358	Two members of the VEGF family, VEGF-C and VEGF-D are lymphangiogenic when activate VEGFR-3.
5	16209358	Finally, podoplanin is a glomerular podocyte membrane mucoprotein, which occurs together with VEGFR-3 in the lymphatic endothelium.
6	16209358	Two members of the VEGF family, VEGF-C and VEGF-D are lymphangiogenic when activate VEGFR-3.
7	16209358	Finally, podoplanin is a glomerular podocyte membrane mucoprotein, which occurs together with VEGFR-3 in the lymphatic endothelium.
8	16525158	Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3.
9	16525158	As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 dependent.
10	16525158	VEGF-C protein expression was localized to podocytes in contrast to VEGF-D, which was expressed in parietal epithelial cells.
11	16525158	Cytotoxicity experiments revealed that in hCIPs VEGF-C reduced cytotoxicity to 81.4+/-1.9% of serum-starved conditions (P<0.001, paired t-test, n=16), similar to VEGF-A (82.8+/-4.5% of serum-starved conditions, P<0.05, paired t-test).
12	16525158	VEGF-C was also shown to induce a 0.5+/-0.13-fold reduction in levels of MAPK phosphorylation compared with VEGF-A and VEGF-A-Mab treatment (P<0.05, ANOVA, n=4), yet had no effect on Akt phosphorylation.
13	16525158	Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3.
14	16525158	As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 dependent.
15	16525158	VEGF-C protein expression was localized to podocytes in contrast to VEGF-D, which was expressed in parietal epithelial cells.
16	16525158	Cytotoxicity experiments revealed that in hCIPs VEGF-C reduced cytotoxicity to 81.4+/-1.9% of serum-starved conditions (P<0.001, paired t-test, n=16), similar to VEGF-A (82.8+/-4.5% of serum-starved conditions, P<0.05, paired t-test).
17	16525158	VEGF-C was also shown to induce a 0.5+/-0.13-fold reduction in levels of MAPK phosphorylation compared with VEGF-A and VEGF-A-Mab treatment (P<0.05, ANOVA, n=4), yet had no effect on Akt phosphorylation.
18	16773315	TR-LE cells expressed lymphatic endothelial markers VEGFR-3 (vascular endothelial growth factor receptor), LYVE-1 (a lymphatic endothelial receptor), Prox-1 (a homeobox gene product), and podoplanin (a glomerular podocyte membrane mucoprotein), together with endothelial markers CD31, Tie-2, and VEGFR-2, whereas TR-BE cells expressed CD31, Tie-2, and VEGFR-2, but no lymphatic endothelial markers.
19	18772335	We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2).
20	18772335	Here we define VEGFR-3 expression in GEnC and investigate the effects of the ligand VEGF-C.
21	18772335	VEGF-C effects on trans-endothelial electrical resistance and albumin flux across GEnC monolayers were measured.
22	18772335	VEGF-C effects on intracellular calcium ([Ca2+]i) were measured using a fluorescence technique, receptor phosphorylation was examined by immunoprecipitation assays, and phosphorylation of myosin light chain-2 and VE-cadherin was assessed by blotting with phospho-specific antibodies.
23	18772335	GEnC expressed VEGFR-3 in tissue sections and culture, and VEGF-C increased trans-endothelial electrical resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-C156S had no effect.
24	18772335	VEGF-C reduced labeled albumin flux by 32.8%.
25	18772335	VEGF-C and VEGF-A increased [Ca2+]i by 15% and 39%, respectively.
26	18772335	VEGF-C phosphorylated VEGFR-2 but not VEGFR-3, myosin light chain-2, or VE-cadherin.
27	18772335	These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A.
28	18772335	We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2).
29	18772335	Here we define VEGFR-3 expression in GEnC and investigate the effects of the ligand VEGF-C.
30	18772335	VEGF-C effects on trans-endothelial electrical resistance and albumin flux across GEnC monolayers were measured.
31	18772335	VEGF-C effects on intracellular calcium ([Ca2+]i) were measured using a fluorescence technique, receptor phosphorylation was examined by immunoprecipitation assays, and phosphorylation of myosin light chain-2 and VE-cadherin was assessed by blotting with phospho-specific antibodies.
32	18772335	GEnC expressed VEGFR-3 in tissue sections and culture, and VEGF-C increased trans-endothelial electrical resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-C156S had no effect.
33	18772335	VEGF-C reduced labeled albumin flux by 32.8%.
34	18772335	VEGF-C and VEGF-A increased [Ca2+]i by 15% and 39%, respectively.
35	18772335	VEGF-C phosphorylated VEGFR-2 but not VEGFR-3, myosin light chain-2, or VE-cadherin.
36	18772335	These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A.
37	18772335	We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2).
38	18772335	Here we define VEGFR-3 expression in GEnC and investigate the effects of the ligand VEGF-C.
39	18772335	VEGF-C effects on trans-endothelial electrical resistance and albumin flux across GEnC monolayers were measured.
40	18772335	VEGF-C effects on intracellular calcium ([Ca2+]i) were measured using a fluorescence technique, receptor phosphorylation was examined by immunoprecipitation assays, and phosphorylation of myosin light chain-2 and VE-cadherin was assessed by blotting with phospho-specific antibodies.
41	18772335	GEnC expressed VEGFR-3 in tissue sections and culture, and VEGF-C increased trans-endothelial electrical resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-C156S had no effect.
42	18772335	VEGF-C reduced labeled albumin flux by 32.8%.
43	18772335	VEGF-C and VEGF-A increased [Ca2+]i by 15% and 39%, respectively.
44	18772335	VEGF-C phosphorylated VEGFR-2 but not VEGFR-3, myosin light chain-2, or VE-cadherin.
45	18772335	These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A.
46	19031946	This was mainly due to the discovery of lymphatic endothelial cell (LEC)-specific markers, such as vascular endothelial growth factor receptor-3 (VEGFR-3), LYVE-1, Prox-1 and podoplanin.
47	19031946	The expression of podoplanin is induced by the homeobox gene Prox-1 and a specific endogenous receptor was identified on platelets.
48	29397483	Consistent with these findings, genes known to regulate vessel caliber (Apln, AplnR and Vegfr3) are significantly upregulated in A10ΔEC glomeruli.