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Gene Information
Gene symbol: FN1
Gene name: fibronectin 1
HGNC ID: 3778
Synonyms: MSF, CIG, LETS, GFND2, FINC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTC1 | 1 hits |
| 2 | CD68 | 1 hits |
| 3 | COL1A1 | 1 hits |
| 4 | COL4A1 | 1 hits |
| 5 | IL6 | 1 hits |
| 6 | ITGB6 | 1 hits |
| 7 | MMP9 | 1 hits |
| 8 | NPHS1 | 1 hits |
| 9 | NPHS2 | 1 hits |
| 10 | PXN | 1 hits |
| 11 | SLC45A2 | 1 hits |
| 12 | STAT3 | 1 hits |
| 13 | TGFB1 | 1 hits |
| 14 | VCL | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19211686 | Real-time PCR demonstrated increased glomerular expression of Col4a1, Fn1, and Tgfb1. |
| 2 | 23710468 | Compared to KK-a/a controls, 26-week-old KK-A (y) mice had elevated HbA1c, insulin, leptin, triglycerides, and cholesterol, and Unx further elevated these markers of metabolic dysregulation. |
| 3 | 23710468 | Consistent with functional and histological evidence of increased injury, fibrotic (fibronectin 1, MMP9, and TGF β 1) and inflammatory (IL-6, CD68) genes were markedly upregulated in Unx KK-A (y) mice, while podocyte markers (nephrin and podocin) were significantly decreased. |
| 4 | 26687735 | Preparation of PCKSs induced an inflammatory tissue response, whereas long-term incubation (96 hours) induced fibrogenesis as shown by an increased expression of collagen type 1A1 (COL1A1) and fibronectin 1 (FN1). |
| 5 | 26687735 | Moreover, TGF-β1 exposure augmented fibrosis, as illustrated by an increased expression of multiple fibrosis markers including COL1A1, FN1, and α-smooth muscle actin. |
| 6 | 26687735 | Preparation of PCKSs induced an inflammatory tissue response, whereas long-term incubation (96 hours) induced fibrogenesis as shown by an increased expression of collagen type 1A1 (COL1A1) and fibronectin 1 (FN1). |
| 7 | 26687735 | Moreover, TGF-β1 exposure augmented fibrosis, as illustrated by an increased expression of multiple fibrosis markers including COL1A1, FN1, and α-smooth muscle actin. |
| 8 | 31675484 | Furthermore, Fn1 KO podocytes showed a significant down-regulation of the focal adhesion proteins talin, vinculin, and paxillin and a reduced cell spreading, indicating an important role of Fn1 in adhesion. |
| 9 | 34516901 | Integration with in silico chromatin immunoprecipitation identified key ligand-receptor interactions, such as fibronectin 1 (FN1)–αVβ6, between podocytes and PECs dependent on KLF4 and downstream signal transducer and activator of transcription 3 (STAT3) signaling. |
| 10 | 34516901 | Additionally, podocyte-specific induction of human KLF4 or pharmacological inhibition of downstream STAT3 activation reduced FN1 and integrin β 6 (ITGB6) expression and mitigated podocyte loss and PEC activation in mice. |
| 11 | 34516901 | Integration with in silico chromatin immunoprecipitation identified key ligand-receptor interactions, such as fibronectin 1 (FN1)–αVβ6, between podocytes and PECs dependent on KLF4 and downstream signal transducer and activator of transcription 3 (STAT3) signaling. |
| 12 | 34516901 | Additionally, podocyte-specific induction of human KLF4 or pharmacological inhibition of downstream STAT3 activation reduced FN1 and integrin β 6 (ITGB6) expression and mitigated podocyte loss and PEC activation in mice. |