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Gene Information
Gene symbol: GGA2
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD2AP | 1 hits |
| 2 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26546360 | Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. |
| 2 | 26546360 | The adapter protein CD2-associated protein (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or trafficking and degradation pathways. |
| 3 | 26546360 | Here, we investigated the role of CD2AP in insulin-dependent glucose transporter 4 (Glut4, also known as SLC2A4) trafficking and glucose uptake. |
| 4 | 26546360 | In subcellular membrane fractionations, CD2AP co-fractionated with Glut4, IRAP (also known as LNPEP) and sortilin, constituents of Glut4 storage vesicles (GSVs). |
| 5 | 26546360 | We further found that CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process. |
| 6 | 26546360 | This leads to reduced insulin-stimulated trafficking of GSVs and attenuated glucose uptake into CD2AP(-/-) podocytes. |