Ignet

Gene Information

Gene symbol: GPR172A

Gene name: G protein-coupled receptor 172A

HGNC ID: 30224

Related Genes

#	Gene Symbol	Number of hits
1	F2	1 hits
2	F2RL2	1 hits
3	F2RL3	1 hits
4	GPR172B	1 hits
5	MARK2	1 hits
6	NR1I2	1 hits

Related Sentences

#	PMID	Sentence
1	27733370	Protease-activated receptors (PARs) are members of a well-known family of transmembrane G protein-coupled receptors (GPCRs).
2	27733370	Four PARs have been identified to date, of which PAR1 and PAR2 are the most abundant receptors, and have been shown to be expressed in the kidney vascular and tubular cells.
3	27733370	The receptors are activated by endogenous serine proteases, such as thrombin (acts on PARs 1, 3, and 4) and trypsin (PAR2).
4	27733370	Clinical studies further demonstrated that the concentration of urinary thrombin is associated with glomerulonephritis and type 2 diabetic nephropathy; thus, molecular and functional mechanisms of PARs activation can be directly involved in renal disease progression.
5	27733370	We briefly discuss here the recent literature related to activation of PAR signaling in glomeruli and the kidney in general and provide some examples of PAR1 signaling in glomeruli podocytes.
6	27733370	Protease-activated receptors (PARs) are members of a well-known family of transmembrane G protein-coupled receptors (GPCRs).
7	27733370	Four PARs have been identified to date, of which PAR1 and PAR2 are the most abundant receptors, and have been shown to be expressed in the kidney vascular and tubular cells.
8	27733370	The receptors are activated by endogenous serine proteases, such as thrombin (acts on PARs 1, 3, and 4) and trypsin (PAR2).
9	27733370	Clinical studies further demonstrated that the concentration of urinary thrombin is associated with glomerulonephritis and type 2 diabetic nephropathy; thus, molecular and functional mechanisms of PARs activation can be directly involved in renal disease progression.
10	27733370	We briefly discuss here the recent literature related to activation of PAR signaling in glomeruli and the kidney in general and provide some examples of PAR1 signaling in glomeruli podocytes.
11	27733370	Protease-activated receptors (PARs) are members of a well-known family of transmembrane G protein-coupled receptors (GPCRs).
12	27733370	Four PARs have been identified to date, of which PAR1 and PAR2 are the most abundant receptors, and have been shown to be expressed in the kidney vascular and tubular cells.
13	27733370	The receptors are activated by endogenous serine proteases, such as thrombin (acts on PARs 1, 3, and 4) and trypsin (PAR2).
14	27733370	Clinical studies further demonstrated that the concentration of urinary thrombin is associated with glomerulonephritis and type 2 diabetic nephropathy; thus, molecular and functional mechanisms of PARs activation can be directly involved in renal disease progression.
15	27733370	We briefly discuss here the recent literature related to activation of PAR signaling in glomeruli and the kidney in general and provide some examples of PAR1 signaling in glomeruli podocytes.
16	27733370	Protease-activated receptors (PARs) are members of a well-known family of transmembrane G protein-coupled receptors (GPCRs).
17	27733370	Four PARs have been identified to date, of which PAR1 and PAR2 are the most abundant receptors, and have been shown to be expressed in the kidney vascular and tubular cells.
18	27733370	The receptors are activated by endogenous serine proteases, such as thrombin (acts on PARs 1, 3, and 4) and trypsin (PAR2).
19	27733370	Clinical studies further demonstrated that the concentration of urinary thrombin is associated with glomerulonephritis and type 2 diabetic nephropathy; thus, molecular and functional mechanisms of PARs activation can be directly involved in renal disease progression.
20	27733370	We briefly discuss here the recent literature related to activation of PAR signaling in glomeruli and the kidney in general and provide some examples of PAR1 signaling in glomeruli podocytes.