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Gene Information

Gene symbol: HMGB1

Gene name: high mobility group box 1

HGNC ID: 4983

Synonyms: HMG3, SBP-1, DKFZp686A04236

Related Genes

#	Gene Symbol	Number of hits
1	CLEC14A	1 hits
2	EGR1	1 hits
3	S100A1	1 hits
4	S100B	1 hits
5	TLR2	1 hits
6	TLR4	1 hits

Related Sentences

#	PMID	Sentence
1	34107098	In this study, we found that CLEC14A was expressed in podocyte and protected against podocyte injury in mice with Adriamycin (ADR)-induced FSGS.
2	34107098	Mechanistically, CLEC14A inhibited high-mobility group box 1 protein (HMGB1) release, at least in part by directly binding HMGB1, and suppressed HMGB1-mediated signaling, including NF-κB signaling and early growth response protein 1 (EGR1) signaling.
3	29844451	Activation of TLR2 or TLR4 by endogenous ligands such as high mobility group box 1 (HMGB1) may mediate inflammation causing diabetic kidney injury.
4	29844451	To determine the mechanism(s) of protection, we found that whilst deficiency of TLR2, TLR4 or RAGE afforded partial protection from development of DN, over-expression of esRAGE provided additional protection in TLR2-/-, modest protection against podocyte damage only in TLR4-/- and no protection in RAGE-/- diabetic mice, suggesting the protection provided by esRAGE was primarily through interruption of RAGE and TLR4 pathways.
5	22067944	We showed that during renal I/R, RAGE ligands HMGB1 and S100B are expressed.
6	16037278	Although RAGE was first described as a receptor for advanced glycation end products (AGEs), the key finding that RAGE was also a signaling receptor for proinflammatory S100/calgranulins and amphoterin, led to the premise that even in euglycemia, ligand-RAGE interaction propagated inflammatory mechanisms linked to chronic cellular perturbation and tissue injury.