Ignet

Gene Information

Gene symbol: HPX

Gene name: hemopexin

HGNC ID: 5171

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ALB	1 hits
3	CLCF1	1 hits
4	HP	1 hits
5	IL13	1 hits
6	IL6	1 hits
7	INS	1 hits
8	NPHS1	1 hits
9	NPHS2	1 hits
10	PLAT	1 hits

Related Sentences

#	PMID	Sentence
1	18753258	Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.
2	18753258	Furthermore, hemopexin did not affect actin organization in cells that do not express nephrin, specifically human glomerular endothelial cells, fibroblasts, and HEK293 cells.
3	18753258	Treatment with hemopexin activated protein kinase B in both wild-type and nephrin-deficient podocytes but activated RhoA only in wild-type cells.
4	18753258	In addition, hemopexin led to a selective increase in the passage of albumin across monolayers of glomerular endothelial cells and to a reduction in glycocalyx.
5	18753258	In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx.
6	18753258	Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.
7	18753258	Furthermore, hemopexin did not affect actin organization in cells that do not express nephrin, specifically human glomerular endothelial cells, fibroblasts, and HEK293 cells.
8	18753258	Treatment with hemopexin activated protein kinase B in both wild-type and nephrin-deficient podocytes but activated RhoA only in wild-type cells.
9	18753258	In addition, hemopexin led to a selective increase in the passage of albumin across monolayers of glomerular endothelial cells and to a reduction in glycocalyx.
10	18753258	In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx.
11	18753258	Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.
12	18753258	Furthermore, hemopexin did not affect actin organization in cells that do not express nephrin, specifically human glomerular endothelial cells, fibroblasts, and HEK293 cells.
13	18753258	Treatment with hemopexin activated protein kinase B in both wild-type and nephrin-deficient podocytes but activated RhoA only in wild-type cells.
14	18753258	In addition, hemopexin led to a selective increase in the passage of albumin across monolayers of glomerular endothelial cells and to a reduction in glycocalyx.
15	18753258	In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx.
16	18753258	Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.
17	18753258	Furthermore, hemopexin did not affect actin organization in cells that do not express nephrin, specifically human glomerular endothelial cells, fibroblasts, and HEK293 cells.
18	18753258	Treatment with hemopexin activated protein kinase B in both wild-type and nephrin-deficient podocytes but activated RhoA only in wild-type cells.
19	18753258	In addition, hemopexin led to a selective increase in the passage of albumin across monolayers of glomerular endothelial cells and to a reduction in glycocalyx.
20	18753258	In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx.
21	18753258	Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.
22	18753258	Furthermore, hemopexin did not affect actin organization in cells that do not express nephrin, specifically human glomerular endothelial cells, fibroblasts, and HEK293 cells.
23	18753258	Treatment with hemopexin activated protein kinase B in both wild-type and nephrin-deficient podocytes but activated RhoA only in wild-type cells.
24	18753258	In addition, hemopexin led to a selective increase in the passage of albumin across monolayers of glomerular endothelial cells and to a reduction in glycocalyx.
25	18753258	In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx.
26	23689570	The characterization of molecules acting as permeability factors, including hemopexin, soluble urokinase receptor and cardiotrophin-like cytokine-1, supports plasma exchange in severe cases of INS, particularly in patients at high risk of recurrence of FSGS after transplantation.
27	25925039	Clinical and experimental data indicate roles for cytokines IL-13, TNFα, circulating cardiotrophin-like cytokine factor 1 (member of the IL-6 family), circulating hemopexin, radical oxygen species, and the soluble urokinase-type plasminogen activator receptor (suPAR) in the development of nephrotic syndrome.
28	25925039	Podocyte metabolism modifications-leading to the overexpression of the podocyte B7-1antigen (CD 80), hypoactivity of the podocyte enzyme sphingomyelin phosphodiesterase acid-like 3 b (SMPDL3b), and to the podocyte production of a hyposialylated form of the angiopoietin-like 4 (Angptl4)-are mechanisms possibly involved in the changes in the podocyte cytoskeleton leading to SSNS and or SRNS.
29	28729288	Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies.
30	28729288	Plasma measurements included HbF concentrations and concentrations of the endogenous chelators haptoglobin, hemopexin, and α_1- microglobulin.
31	28729288	Compared with urine from women with normotensive pregnancies, urine from women with preeclamptic pregnancies contained a high ratio of podocin-positive to nephrin-positive urinary EVs (podocin⁺ EVs-to-nephrin⁺ EVs ratio) and increased nephrinuria, both of which correlated with proteinuria.
32	28729288	Plasma levels of hemopexin, which were decreased in women with preeclampsia, negatively correlated with proteinuria, urinary podocin⁺ EVs-to-nephrin⁺ EVs ratio, and nephrinuria.
33	28729288	Furthermore, renal injury in preeclampsia associated with an elevated urinary podocin⁺ EVs-to-nephrin⁺ EVs ratio and may be mediated by prolonged exposure to cellfree HbF.
34	28729288	Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies.
35	28729288	Plasma measurements included HbF concentrations and concentrations of the endogenous chelators haptoglobin, hemopexin, and α_1- microglobulin.
36	28729288	Compared with urine from women with normotensive pregnancies, urine from women with preeclamptic pregnancies contained a high ratio of podocin-positive to nephrin-positive urinary EVs (podocin⁺ EVs-to-nephrin⁺ EVs ratio) and increased nephrinuria, both of which correlated with proteinuria.
37	28729288	Plasma levels of hemopexin, which were decreased in women with preeclampsia, negatively correlated with proteinuria, urinary podocin⁺ EVs-to-nephrin⁺ EVs ratio, and nephrinuria.
38	28729288	Furthermore, renal injury in preeclampsia associated with an elevated urinary podocin⁺ EVs-to-nephrin⁺ EVs ratio and may be mediated by prolonged exposure to cellfree HbF.