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Gene Information
Gene symbol: IDH2
Gene name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
HGNC ID: 5383
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SIRT3 | 1 hits |
| 2 | SOD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26424786 | Treatment of diabetic db/db mice with the selective TGR5 agonist INT-777 decreased proteinuria, podocyte injury, mesangial expansion, fibrosis, and CD68 macrophage infiltration in the kidney. |
| 2 | 26424786 | INT-777 also induced renal expression of master regulators of mitochondrial biogenesis, inhibitors of oxidative stress, and inducers of fatty acid β-oxidation, including sirtuin 1 (SIRT1), sirtuin 3 (SIRT3), and Nrf-1. |
| 3 | 26424786 | Increased activity of SIRT3 was evidenced by normalization of the increased acetylation of mitochondrial superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2) observed in untreated db/db mice. |