Ignet

Gene Information

Gene symbol: IGFBP1

Gene name: insulin-like growth factor binding protein 1

HGNC ID: 5469

Synonyms: IGF-BP25, AFBP, hIGFBP-1, PP12

Related Genes

#	Gene Symbol	Number of hits
1	CDKN1A	1 hits
2	FOXO1	1 hits
3	G6PC	1 hits
4	IGF1	1 hits
5	IGFBP2	1 hits
6	IGFBP3	1 hits
7	IGFBP4	1 hits
8	PDK4	1 hits
9	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	17011663	Insulin-like growth factors (IGFs) and the high affinity IGF binding proteins (IGFBPs) exert major effects on cell growth and metabolism.
2	17011663	Compared with diabetic patients without microalbuminuria (MA), MA diabetic patients display perturbed GH-IGF-IGFBP homeostasis, including increased circulating IGF-I and IGFBP-3 protease activity, increased excretion of bioactive GH, IGF-I, and IGFBP-3, but decreased circulating IGFBP-3 levels.
3	17011663	In diabetic animal models, expression of IGF-I and IGFBP-1 to -4 increases in key renal tissues and glomerular ulrafiltrate.
4	20102313	Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease.
5	20102313	We found that patients with active FSGS excrete high amounts of podocalyxin positive cells as well as IGFBP-1 and -3.
6	20102313	In human podocytes, we can induce mRNA expression of IGFBP-3 in response to TGF-beta and in human microvascular endothelial cells expression of IGFBP-1 and -3 in response to TGF-beta and Bradykinin.
7	20102313	We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS.
8	20102313	Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease.
9	20102313	We found that patients with active FSGS excrete high amounts of podocalyxin positive cells as well as IGFBP-1 and -3.
10	20102313	In human podocytes, we can induce mRNA expression of IGFBP-3 in response to TGF-beta and in human microvascular endothelial cells expression of IGFBP-1 and -3 in response to TGF-beta and Bradykinin.
11	20102313	We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS.
12	20102313	Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease.
13	20102313	We found that patients with active FSGS excrete high amounts of podocalyxin positive cells as well as IGFBP-1 and -3.
14	20102313	In human podocytes, we can induce mRNA expression of IGFBP-3 in response to TGF-beta and in human microvascular endothelial cells expression of IGFBP-1 and -3 in response to TGF-beta and Bradykinin.
15	20102313	We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS.
16	20102313	Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease.
17	20102313	We found that patients with active FSGS excrete high amounts of podocalyxin positive cells as well as IGFBP-1 and -3.
18	20102313	In human podocytes, we can induce mRNA expression of IGFBP-3 in response to TGF-beta and in human microvascular endothelial cells expression of IGFBP-1 and -3 in response to TGF-beta and Bradykinin.
19	20102313	We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS.
20	26747726	Metabolic memory by palmitate was found to be associated with increased FOXO1 activity as evident from increased expression of FOXO1 target genes such as PDK4, p21, G6Pc and IGFBP1.