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Gene Information
Gene symbol: IL2RA
Gene name: interleukin 2 receptor, alpha
HGNC ID: 6008
Synonyms: CD25
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | IL15 | 1 hits |
| 3 | IL2 | 1 hits |
| 4 | IL2RB | 1 hits |
| 5 | IL2RG | 1 hits |
| 6 | IL5 | 1 hits |
| 7 | ITGAM | 1 hits |
| 8 | NT5E | 1 hits |
| 9 | RAG2 | 1 hits |
| 10 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 32776181 | The patient exhibited low-grade fever, systemic inflammatory reactions, multiple lung lesions, and persistent proteinuria, which were closely correlated with changes in serum titers of proteinase-3- and myeloperoxidase-ANCA. |
| 2 | 32776181 | The ANCA titers decreased in parallel with reductions in the serum levels of the soluble interleukin-2 receptor, suggestive of an association between changes in ANCA levels and IVLBCL-related vascular injuries. |
| 3 | 28318628 | There was a significantly decreased percentage of natural killer (NK) cells with an increase in the CD56brightCD16-/lo NK subset. |
| 4 | 28318628 | There were a significantly decreased percentage of regulatory T cells, together with an increased plasma concentration of TNF-alpha, IL-5 and IL-2RA. |
| 5 | 28318628 | After rituximab, B-cell recovery was still incomplete at six months, with persistent alterations of B-cell subsets, a significant increase of both T-regulatory (Treg) cells and NK cells, and a significant decrease of both the CD56brightCD16-/lo NK subset and TNF-alpha levels. |
| 6 | 28111009 | Anti-GBM-GN was induced in three strains of immune-deficient mice (Rag2-/-, Rag2-/-Il2rg-/-, and Rag2-/-Il2rb-/-) that are devoid of either T/B cells or T/B/NK cells. |
| 7 | 28111009 | The Rag2-/-Il2rg-/- or Rag2-/-Il2rb-/- mice harbor an additional deletion of either the common gamma chain (γC) or the interleukin-2 receptor β subunit (IL-2Rβ), respectively, impairing IL-15 signaling in particular. |
| 8 | 28111009 | Given that IL-15 has been found highly expressed in nephritic kidneys despite the absence of lymphocytes, we then studied this cytokine in vitro on primary cultured podocytes from immune-deficient mice (Rag2-/-Il2rg-/- and Rag2-/-Il2rb-/-) compared to controls. |
| 9 | 28111009 | IL-15 induced downstream activation of JAK1/3 and SYK in primary cultured podocytes. |
| 10 | 28111009 | IL-15-dependent JAK/SYK induction was impaired in the absence of γC or IL-2Rβ. |
| 11 | 22666342 | We observed autoimmune inflammation in CD73(-/-)mice with glomerulitis and peritubular capillaritis, showing glomerular deposition of IgG and C3 and enhanced presence of CD11b, CD8, CD25 as well as GR-1-positive cells in the interstitium. |
| 12 | 22666342 | Vascular inflammation was associated with enhanced serum levels of the cytokines IL-18 and TNF-α as well as VEGF and the chemokine MIP-2 (CXCL-2) in CD73(-/-)mice, whereas chemokines and cytokines in the kidney tissue were unaltered or reduced. |