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Gene Information
Gene symbol: IL4R
Gene name: interleukin 4 receptor
HGNC ID: 6015
Synonyms: CD124
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL13 | 1 hits |
| 2 | IL13RA2 | 1 hits |
| 3 | IL4 | 1 hits |
| 4 | NOS2A | 1 hits |
| 5 | NPHS1 | 1 hits |
| 6 | NPHS2 | 1 hits |
| 7 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17429054 | Serum IL-13, albumin, cholesterol, and creatinine and urine albumin were measured serially. |
| 2 | 17429054 | Glomerular gene expression of nephrin, podocin, dystroglycan, B7-1, and IL-13 receptor subunits were examined using real-time PCR with hybridization probes and expressed as an index against beta-actin. |
| 3 | 17429054 | Glomerular gene expression was significantly upregulated for B7-1, IL-4Ralpha, and IL-13Ralpha2 but downregulated for nephrin, podocin, and dystroglycan. |
| 4 | 17429054 | Immunofluorescence staining intensity was reduced for nephrin, podocin, and dystroglycan but increased for B7-1 and IL-4Ralpha in IL-13-transfected rats compared with controls. |
| 5 | 17429054 | In conclusion, these results suggest that IL-13 overexpression in the rat could lead to podocyte injury with downregulation of nephrin, podocin, and dystroglycan and a concurrent upregulation of B7-1 in the glomeruli, inducing a minimal change-like nephropathy that is characterized by increased proteinuria, hypoalbuminemia, hypercholesterolemia, and fusion of podocyte foot processes. |
| 6 | 17429054 | Serum IL-13, albumin, cholesterol, and creatinine and urine albumin were measured serially. |
| 7 | 17429054 | Glomerular gene expression of nephrin, podocin, dystroglycan, B7-1, and IL-13 receptor subunits were examined using real-time PCR with hybridization probes and expressed as an index against beta-actin. |
| 8 | 17429054 | Glomerular gene expression was significantly upregulated for B7-1, IL-4Ralpha, and IL-13Ralpha2 but downregulated for nephrin, podocin, and dystroglycan. |
| 9 | 17429054 | Immunofluorescence staining intensity was reduced for nephrin, podocin, and dystroglycan but increased for B7-1 and IL-4Ralpha in IL-13-transfected rats compared with controls. |
| 10 | 17429054 | In conclusion, these results suggest that IL-13 overexpression in the rat could lead to podocyte injury with downregulation of nephrin, podocin, and dystroglycan and a concurrent upregulation of B7-1 in the glomeruli, inducing a minimal change-like nephropathy that is characterized by increased proteinuria, hypoalbuminemia, hypercholesterolemia, and fusion of podocyte foot processes. |
| 11 | 27815317 | Cultured macrophages with COX-2 deletion exhibited an M1 phenotype, as demonstrated by higher inducible nitric oxide synthase and nuclear factor-κB levels but lower interleukin-4 receptor-α levels. |