Ignet

Gene Information

Gene symbol: INPPL1

Gene name: inositol polyphosphate phosphatase-like 1

HGNC ID: 6080

Synonyms: SHIP2

Related Genes

#	Gene Symbol	Number of hits
1	ABL1	1 hits
2	AGT	1 hits
3	AKT1	1 hits
4	CD2	1 hits
5	CD2AP	1 hits
6	FCGR3A	1 hits
7	INS	1 hits
8	NPHS1	1 hits
9	PIB5PA	1 hits
10	PIK3CA	1 hits
11	RAPH1	1 hits
12	SH2D5	1 hits
13	SLC2A4	1 hits
14	SRC	1 hits
15	SYNJ1	1 hits

Related Sentences

#	PMID	Sentence
1	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
2	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
3	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
4	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
5	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
6	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
7	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
8	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
9	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
10	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
11	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
12	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
13	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
14	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
15	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
16	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
17	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
18	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
19	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
20	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
21	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
22	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
23	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
24	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
25	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
26	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
27	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
28	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
29	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
30	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
31	20654688	Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
32	20654688	To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
33	20654688	SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
34	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
35	20654688	SHIP2 is upregulated in glomeruli of insulin resistant obese Zucker rats.
36	20654688	These results indicate that SHIP2 downregulates insulin signalling in podocytes.
37	22194892	Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
38	22194892	Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase), Filamin and Lamellipodin, proteins important in regulation of actin and focal adhesion dynamics, as well as lamellipodia formation.
39	22194892	Using the previously described CD16-Nephrin clustering system, Nephrin ligation or activation resulted in phosphorylation of the actin crosslinking protein Filamin in a p21 activated kinase dependent manner.
40	22194892	In the CD16-Nephrin clustering model, Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
41	22194892	Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
42	22194892	Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase), Filamin and Lamellipodin, proteins important in regulation of actin and focal adhesion dynamics, as well as lamellipodia formation.
43	22194892	Using the previously described CD16-Nephrin clustering system, Nephrin ligation or activation resulted in phosphorylation of the actin crosslinking protein Filamin in a p21 activated kinase dependent manner.
44	22194892	In the CD16-Nephrin clustering model, Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
45	22194892	Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
46	22194892	Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase), Filamin and Lamellipodin, proteins important in regulation of actin and focal adhesion dynamics, as well as lamellipodia formation.
47	22194892	Using the previously described CD16-Nephrin clustering system, Nephrin ligation or activation resulted in phosphorylation of the actin crosslinking protein Filamin in a p21 activated kinase dependent manner.
48	22194892	In the CD16-Nephrin clustering model, Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
49	26510503	Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl.
50	26510503	Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase that is involved in cell survival and regulation of the cytoskeleton.
51	26510503	Phosphorylated nephrin is able to interact with molecules containing SH2/SH3 domains, suggesting that c-Abl may be a downstream molecule of nephrin signaling.
52	26510503	Here we report that Ang II-infused rats developed proteinuria and podocyte damage accompanied by nephrin dephosphorylation and minimal interaction between nephrin and c-Abl.
53	26510503	In vitro, Ang II induced podocyte injury and nephrin and Akt dephosphorylation, which occurred in tandem with minimal interaction between nephrin and c-Abl.
54	26510503	Moreover, Ang II promoted c-Abl phosphorylation and interaction between c-Abl and SH2 domain-containing 5'-inositol phosphatase 2 (SHIP2). c-Abl small interfering RNA (siRNA) and STI571 (c-Abl inhibitor) provided protection against Ang II-induced podocyte injury, suppressed the Ang II-induced c-Abl-SHIP2 interaction and SHIP2 phosphorylation, and maintained a stable level of nephrin phosphorylation.
55	26510503	These results indicate that c-Abl is a molecular chaperone of nephrin signaling and the SHIP2-Akt pathway and that the released c-Abl contributes to Ang II-induced podocyte injury.
56	28878342	Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis.
57	28878342	Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure.
58	28878342	We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP.
59	28878342	PDK1 and CDK2, central regulators of AKT, were downregulated in CD2AP-/- or PA-treated podocytes.
60	28878342	Downregulation of PDK1 and CDK2, ROS generation and apoptosis were prevented by CD2AP overexpression in both models.
61	28878342	AKT- and ERK-mediated signalling was diminished and remained reduced after AS1949490 treatment in the absence of CD2AP.
62	28878342	Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis.
63	28878342	Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure.
64	28878342	We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP.
65	28878342	PDK1 and CDK2, central regulators of AKT, were downregulated in CD2AP-/- or PA-treated podocytes.
66	28878342	Downregulation of PDK1 and CDK2, ROS generation and apoptosis were prevented by CD2AP overexpression in both models.
67	28878342	AKT- and ERK-mediated signalling was diminished and remained reduced after AS1949490 treatment in the absence of CD2AP.
68	30321069	Lipid phosphatase Src homology 2 domain-containing inositol-5-phosphatase 2 (SHIP2) is upregulated in diabetic rodent models and suppresses insulin signaling by reducing Akt activation, leading to insulin resistance and diminished glucose uptake.
69	30321069	In SHIP2-overexpressing myotubes, metformin ameliorates reduced glucose uptake by slowing down glucose transporter 4 endocytosis.
70	30321069	SHIP2 overexpression reduces Akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin.
71	30321069	Lipid phosphatase Src homology 2 domain-containing inositol-5-phosphatase 2 (SHIP2) is upregulated in diabetic rodent models and suppresses insulin signaling by reducing Akt activation, leading to insulin resistance and diminished glucose uptake.
72	30321069	In SHIP2-overexpressing myotubes, metformin ameliorates reduced glucose uptake by slowing down glucose transporter 4 endocytosis.
73	30321069	SHIP2 overexpression reduces Akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin.
74	30321069	Lipid phosphatase Src homology 2 domain-containing inositol-5-phosphatase 2 (SHIP2) is upregulated in diabetic rodent models and suppresses insulin signaling by reducing Akt activation, leading to insulin resistance and diminished glucose uptake.
75	30321069	In SHIP2-overexpressing myotubes, metformin ameliorates reduced glucose uptake by slowing down glucose transporter 4 endocytosis.
76	30321069	SHIP2 overexpression reduces Akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin.
77	31342643	SHIP2 (Src homology 2 domain-containing inositol 5'-phosphatase 2) belongs to the family of 5'-phosphatases.
78	31342643	It regulates the phosphoinositide 3-kinase (PI3K)-mediated insulin signalling cascade by dephosphorylating the 5'-position of PtdIns(3,4,5)P3 to generate PtdIns(3,4)P2, suppressing the activity of the pathway.
79	31342643	This review summarizes the central mechanisms associated with the development of diabetic kidney disease, including the role of insulin resistance, and then moves on to describe the function of SHIP2 as a regulator of metabolism in mouse models.
80	31342643	SHIP2 (Src homology 2 domain-containing inositol 5'-phosphatase 2) belongs to the family of 5'-phosphatases.
81	31342643	It regulates the phosphoinositide 3-kinase (PI3K)-mediated insulin signalling cascade by dephosphorylating the 5'-position of PtdIns(3,4,5)P3 to generate PtdIns(3,4)P2, suppressing the activity of the pathway.
82	31342643	This review summarizes the central mechanisms associated with the development of diabetic kidney disease, including the role of insulin resistance, and then moves on to describe the function of SHIP2 as a regulator of metabolism in mouse models.