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Gene Information
Gene symbol: IPPK
Gene name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
HGNC ID: 14645
Synonyms: INSP5K2, FLJ13163, IP5K, IPK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ITPR1 | 1 hits |
| 2 | PLCG1 | 1 hits |
| 3 | RYR1 | 1 hits |
| 4 | TRPC3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25521631 | Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. |
| 2 | 25521631 | In eukaryotic cells, activation of phospholipase C (PLC)-coupled membrane receptors by hormones leads to an increase in the intracellular Ca(2+) concentration [Ca(2+) ]i . |
| 3 | 25521631 | Catalytic activity of PLCs results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) which opens DAG-sensitive classical transient receptor channels 3, 6, and 7 (TRPC3/6/7), initiating Ca(2+) influx from the extracellular space. |
| 4 | 25521631 | PLCε-/- podocytes however, were undistinguishable from WT podocytes in their angiotensin II-induced formation of actin stress fibers and their GTPγS-induced TRPC6 activation, pointing to a redundant role of PLCε-mediated TRPC6 activation at least in podocytes. |
| 5 | 28181698 | The intracellular calcium chelator, 1,2-bis (2-aminophenoxy) ethane-N,N,N, N'-tetraacetic acid tetrakis acetoxymethyl ester (BAPTA-AM), partially prevented this upregulation whereas 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-triphosphate receptor (IP3R) inhibitor; dantrolene, a ryanodine receptor (RyR) inhibitor; and 4,4'-diisothiocyanatostibene-2,2'-disulfonic acid (DIDS), an anion exchange inhibitor, had no effect. |