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Gene Information
Gene symbol: IRF4
Gene name: interferon regulatory factor 4
HGNC ID: 6119
Synonyms: LSIRF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NFKB1 | 1 hits |
| 2 | PLA2R1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 32664235 | Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes. |
| 2 | 32664235 | Primary membranous nephropathy is usually caused by antibodies against the podocyte antigen membrane M-type phospholipase A2 receptor (PLA2R). |
| 3 | 32664235 | We have now identified key TNF receptor superfamily members in podocytes and explored the regulation of PLA2R expression and the impact of tacrolimus. |
| 4 | 32664235 | Data mining of single cell transcriptomics and glomerular transcriptomics data identified TNFRSF12a/Fn14 as the highest expressed TNF receptor superfamily gene in human membranous nephropathy, and this was confirmed by immunohistochemistry that also identified NFκB activation in membranous nephropathy podocytes. |
| 5 | 32664235 | Furthermore, in cultured human podocytes, TWEAK increased the expression of PLA2R as well as the expression of other genes recently identified by GWAS as linked to membranous nephropathy: NFKB1 and IRF4. |
| 6 | 32664235 | Interestingly, IRF4 encodes the FK506-binding protein 52 (FKBP52), a protein associated with tacrolimus. |
| 7 | 32664235 | Tacrolimus prevented the increased expression of PLA2R, NFKB1 and IRF4 induced by TWEAK in cultured podocytes. |
| 8 | 32664235 | Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes. |
| 9 | 32664235 | Primary membranous nephropathy is usually caused by antibodies against the podocyte antigen membrane M-type phospholipase A2 receptor (PLA2R). |
| 10 | 32664235 | We have now identified key TNF receptor superfamily members in podocytes and explored the regulation of PLA2R expression and the impact of tacrolimus. |
| 11 | 32664235 | Data mining of single cell transcriptomics and glomerular transcriptomics data identified TNFRSF12a/Fn14 as the highest expressed TNF receptor superfamily gene in human membranous nephropathy, and this was confirmed by immunohistochemistry that also identified NFκB activation in membranous nephropathy podocytes. |
| 12 | 32664235 | Furthermore, in cultured human podocytes, TWEAK increased the expression of PLA2R as well as the expression of other genes recently identified by GWAS as linked to membranous nephropathy: NFKB1 and IRF4. |
| 13 | 32664235 | Interestingly, IRF4 encodes the FK506-binding protein 52 (FKBP52), a protein associated with tacrolimus. |
| 14 | 32664235 | Tacrolimus prevented the increased expression of PLA2R, NFKB1 and IRF4 induced by TWEAK in cultured podocytes. |