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Gene Information
Gene symbol: JUB
Gene name: jub, ajuba homolog (Xenopus laevis)
HGNC ID: 20250
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PAWR | 1 hits |
| 2 | PDLIM5 | 1 hits |
| 3 | WT1 | 1 hits |
| 4 | WTIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21900451 | WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization. |
| 2 | 21900451 | Wt1-interacting protein (Wtip), an Ajuba family LIM domain scaffold protein expressed in the podocyte, coordinates cell adhesion changes and transcriptional responses to regulate podocyte phenotypic plasticity. |
| 3 | 21900451 | In shWtip cells, cadherin and β-catenin clustered in irregularly distributed spots that failed to laterally expand. |
| 4 | 21900451 | Cell surface biotinylation showed diminished plasma membrane cadherin, β-catenin, and α-catenin in shWtip podocytes, although protein expression was similar in shWtip and control cells. |
| 5 | 21900451 | WTIP directly interacted with Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), a RhoA-specific GEF enriched in the glomerulus. |
| 6 | 21900451 | In conclusion, stable assembly of podocyte adherens junctions and cell-matrix contacts requires Wtip, a process that may be mediated by spatiotemporal regulation of RhoA activity through appropriate targeting of Arhgef12. |