Ignet

Gene Information

Gene symbol: KLHL22

Gene name: kelch-like 22 (Drosophila)

HGNC ID: 25888

Synonyms: FLJ14360, KELCHL

Related Genes

#	Gene Symbol	Number of hits
1	AGT	1 hits
2	BRD4	1 hits
3	INS	1 hits
4	KEAP1	1 hits
5	MAFK	1 hits
6	NFE2L2	1 hits
7	USP15	1 hits

Related Sentences

#	PMID	Sentence
1	29064158	Treatment of mouse mesangial cells with THSG induced nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, increased heme oxygenase-1 and NAD(P)H:quinone oxidoreductase (NQO)-1 gene expressions, and reduced cellular thiol oxidation and resistance to AD-induced cytotoxicity.
2	29064158	Silencing Nrf2 and its repressor protein, Kelch-like ECH-associated protein 1 (Keap1), abolished these protective effects of THSG.
3	31325480	BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling.
4	31325480	Bromodomain-containing protein 4 (BRD4) has emerged as a critical regulator for cell injury.
5	31325480	Moreover, BRD4 inhibition potentiated nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling associated with suppression of Kelch-like ECH-associated protein (Keap1).
6	31325480	BRD4 inhibition promoted Nrf2 nuclear translocation and upregulated the transcriptional activity of Nrf2/antioxidant response element (ARE).
7	31325480	Overall, these results suggest that BRD4 inhibition confers cytoprotection against HG injury in podocytes through potentiation of Nrf2/ARE antioxidant signaling.
8	31325480	This finding implicates BRD4/Nrf2/ARE signaling in the pathogenesis of diabetic nephropathy.
9	32238837	Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes.
10	32238837	Furthermore, linagliptin improved insulin-induced phosphorylation of insulin receptor substrate 1 (IRS1) and Akt, which was inhibited in high-glucose conditions.
11	32238837	Because reactive oxygen species inhibit glomerular insulin signalling in diabetes and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important intrinsic antioxidative systems, we evaluated whether linagliptin increased Nrf2 in podocytes.
12	32238837	In summary, linagliptin offers protection against DKD by enhancing IRS1/Akt insulin signalling in podocytes and partially via the Keap1/Nrf2 pathway.
13	32818518	The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway upregulates key cellular defenses.
14	32818518	To understand this effect, we examined genetically engineered mice with elevated Nrf2 signaling due to reduced expression of the Nrf2 inhibitor, Kelch-like ECH-associated protein 1 (Keap1).
15	32818518	These Keap1^FA/FA mice lacked baseline proteinuria but exhibited increased proteinuria in experimental models evoked by adriamycin, angiotensin II, or protein overload.
16	32818518	After injury, Keap1^FA/FA mice had increased glomerulosclerosis, nephrin disruption and shedding, podocyte injury, foot process effacement, and interstitial fibrosis.
17	32818518	Compared to angiotensin II alone, the combination of angiotensin II and CDDO-Im significantly increased proteinuria, a phenomenon not observed in Nrf2 knockout mice.
18	34426758	Moreover, MitoQ rescued the expression and translocation of Nrf2 (nuclear factor E2-related factor 2) and decreased the expression of Keap1 (Kelch-like ECH-associated protein 1) in Ang II-stimulated podocytes.
19	34426758	Nrf2 knockdown partially blocked the protective effects of MitoQ on Ang II-induced mitochondrial fission and oxidative stress in podocytes.
20	34931430	Inhibition of USP15 ameliorates high-glucose-induced oxidative stress and inflammatory injury in podocytes through regulation of the Keap1/Nrf2 signaling.
21	34931430	Ubiquitin-specific peptidase 15 (USP15) is implicated in the pathogenesis of numerous diseases.
22	34931430	Further investigation showed that inhibition of USP15 enhanced the activation of NF-E2-related factor 2 (Nrf2) and expression of Nrf2 target genes in HG-simulated podocytes.
23	34931430	Moreover, depletion of Kelch-like ECH-associated protein 1 (Keap1) diminished the regulatory effect of USP15 inhibition on Nrf2 activation.
24	34931430	Taken together, these data indicate that USP15 inhibition protects podocytes from HG-induced injury by enhancing Nrf2 activation via Keap1.