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Gene Information
Gene symbol: LAT
Gene name: linker for activation of T cells
HGNC ID: 18874
Synonyms: LAT1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | LAT2 | 1 hits |
| 2 | SLC7A6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21403644 | Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. |
| 2 | 21403644 | Out of three forms of L-type neutral amino acid transporters (LAT1-LAT3) studied here, only LAT2 was found to be upregulated in the PECs and podocytes in advance of the crescent formation as well as in the crescent lesion itself. |
| 3 | 21403644 | Cell culture study revealed that plasma membrane expression of LAT2 markedly stimulated mTORC1 signaling pathway, which was significantly abrogated by coexistence of LAT inhibitor. |
| 4 | 21403644 | Our data suggest that LAT2 may have a pivotal role in the pathogenesis of CGN by activating the mTORC1 pathway in the glomerular epithelial cells. |