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Gene Information
Gene symbol: LATS1
Gene name: LATS, large tumor suppressor, homolog 1 (Drosophila)
HGNC ID: 6514
Synonyms: WARTS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NCK1 | 1 hits |
| 2 | NPHS1 | 1 hits |
| 3 | WTIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27033705 | Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP. |
| 2 | 27033705 | We have previously established that tyrosine phosphorylation of the transmembrane protein nephrin promotes recruitment of the Nck1/2 cytoskeletal adaptor proteins and downstream actin remodeling. |
| 3 | 27033705 | We now reveal that Nck integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. |
| 4 | 27033705 | Using mutational analysis, we show that Nck sequesters WTIP and its binding partner Lats1 to phosphorylated nephrin, resulting in decreased phospho-activation of Lats1. |
| 5 | 27033705 | We further demonstrate that, coincident with nephrin dephosphorylation in a transient model of podocyte injury in mice, Lats1 is rapidly activated, and this precedes significant down-regulation of the transcription regulator Yap. |
| 6 | 27033705 | Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP. |
| 7 | 27033705 | We have previously established that tyrosine phosphorylation of the transmembrane protein nephrin promotes recruitment of the Nck1/2 cytoskeletal adaptor proteins and downstream actin remodeling. |
| 8 | 27033705 | We now reveal that Nck integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. |
| 9 | 27033705 | Using mutational analysis, we show that Nck sequesters WTIP and its binding partner Lats1 to phosphorylated nephrin, resulting in decreased phospho-activation of Lats1. |
| 10 | 27033705 | We further demonstrate that, coincident with nephrin dephosphorylation in a transient model of podocyte injury in mice, Lats1 is rapidly activated, and this precedes significant down-regulation of the transcription regulator Yap. |