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Gene Information
Gene symbol: MAD2L1
Gene name: MAD2 mitotic arrest deficient-like 1 (yeast)
HGNC ID: 6763
Synonyms: MAD2, HSMAD2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDC27 | 1 hits |
| 2 | MAD2L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 34803506 | Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of anaphase-promoting complex (APC)/cyclosome, precisely controls the metaphase to anaphase transition and ordered cell cycle progression. |
| 2 | 34803506 | However, the role of MAD2B in FSGS podocyte injury remains unknown. |
| 3 | 34803506 | Additionally, KU-55933, a specific inhibitor of ataxia-telangiectasia mutated (ATM) was utilized in vivo and in vitro to explore the role of ATM in regulating MAD2B. |
| 4 | 34803506 | Results: The expression of MAD2B in podocytes was dramatically increased in patients with FSGS and ADR-treated mice along with podocyte cell cycle reentry. |
| 5 | 34803506 | By bioinformatics analysis we revealed that ATM kinase is a key upstream regulator of MAD2B. |
| 6 | 34803506 | Furthermore, inhibition of ATM kinase abolished MAD2B-driven cell cycle reentry and alleviated podocyte impairment in FSGS murine model. |
| 7 | 34803506 | In vitro studies by site-directed mutagenesis and immunoprecipitation we revealed ATM phosphorylated MAD2B and consequently hampered the ubiquitination of MAD2B in a phosphorylation-dependent manner. |