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Gene Information
Gene symbol: NELL1
Gene name: NEL-like 1 (chicken)
HGNC ID: 7750
Synonyms: IDH3GL, FLJ45906
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CNTN1 | 1 hits |
| 2 | EXT1 | 1 hits |
| 3 | EXT2 | 1 hits |
| 4 | PLA2G1B | 1 hits |
| 5 | PLA2R1 | 1 hits |
| 6 | SEMA3B | 1 hits |
| 7 | THSD7A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 33042109 | Several auto-antigens have recently been identified in IMN, including M-type receptor for secretory phospholipase A2 (PLA2R1), thrombospondin type-1 domain-containing 7A (THSD7A), and neural epidermal growth factor-like 1 protein (NELL-1). |
| 2 | 33042109 | Induced by environmental stimuli or other causes, the PLA2R1 antigen and/or THSD7A antigen exposed to extrarenal tissues, such as lungs, then produce the auto-antibodies that target and cause damage to the podocytes in circulation. |
| 3 | 33808418 | The clinical management of MN has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) in 2009 and thrombospondin domain-containing 7A (THSD7A) in 2014 on the podocyte surface. |
| 4 | 33808418 | Additionally, evidence is emerging that NELL-1 is associated with 5-10% of PMN cases that are PLA2R- and THSD7A-negative, which moves us one step closer to mapping out the full spectrum of PMN antigens. |
| 5 | 33808418 | Recent developments suggest exostosin 1 (EXT1), EXT2, NELL-1, and contactin 1 (CNTN1) are associated with MN. |
| 6 | 33828546 | It remains to be established if all these relations observed in patients with anti-PLA2R antibodies are also valid for expanding spectrum of antibodies directed against recently discovered minor antigens (e.g., THSD7A, NELL-1, semaphorin 3B). |
| 7 | 35047003 | According to the result of GO and KEGG enrichment, PPI network and Networkanalyst, we screened out six genes (IFI6, MX1, XAF1, HERC6, IFI44L, IFI44). |
| 8 | 35047003 | Interestingly, among PLA2R, THSD7A and NELL1, which are the target antigens of podocyte in MN, the expression level of NELL1 in MN glomerulus is significantly higher than that of LN, while there is no significant difference in the expression level of PLA2R and THSD7A. |
| 9 | 35220046 | In membranous nephropathy (MN), measurement of serum circulating autoantibodies against podocyte transmembrane glycoprotein M-type phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A), immunohistochemical staining of kidney tissue for glomerular PLA2R, THSD7A, neural epidermal growth factor-like 1 protein (NELL-1) and specific types of immunoglobulin G (IgG) may be useful adjuncts when screening for underlying malignancies. |