Ignet

Gene Information

Gene symbol: NES

Gene name: nestin

HGNC ID: 7756

Synonyms: FLJ21841

Related Genes

#	Gene Symbol	Number of hits
1	ACTA1	1 hits
2	ACTC1	1 hits
3	ACTN4	1 hits
4	AGT	1 hits
5	BAP1	1 hits
6	BAX	1 hits
7	BCL2	1 hits
8	CASP3	1 hits
9	CD24	1 hits
10	CD34	1 hits
11	CD36	1 hits
12	CD44	1 hits
13	CD68	1 hits
14	CD79A	1 hits
15	CDH3	1 hits
16	CDK5	1 hits
17	CDK5R1	1 hits
18	CDKN1A	1 hits
19	CLDN1	1 hits
20	CLDN7	1 hits
21	COL1A1	1 hits
22	COL1AR	1 hits
23	COL4A4	1 hits
24	CR1	1 hits
25	CSPG4	1 hits
26	CTGF	1 hits
27	DAG1	1 hits
28	DDN	1 hits
29	DES	1 hits
30	DIAPH1	1 hits
31	EHD3	1 hits
32	ENG	1 hits
33	GAS1	1 hits
34	GJA1	1 hits
35	GSN	1 hits
36	KDR	1 hits
37	KIT	1 hits
38	KRT10	1 hits
39	MKI67	1 hits
40	MSN	1 hits
41	MYH14	1 hits
42	MYH9	1 hits
43	NPHS1	1 hits
44	NPHS2	1 hits
45	PAX2	1 hits
46	PAX8	1 hits
47	PCNA	1 hits
48	PDPN	1 hits
49	PECAM1	1 hits
50	PLA2R1	1 hits
51	PLCE1	1 hits
52	PODXL	1 hits
53	PROM1	1 hits
54	PSMD9	1 hits
55	PTPRO	1 hits
56	RPL10	1 hits
57	RPS27A	1 hits
58	SYNPO	1 hits
59	TCF21	1 hits
60	TJP1	1 hits
61	USP40	1 hits
62	VCAM1	1 hits
63	VEGFA	1 hits
64	VIM	1 hits
65	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
2	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
3	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
4	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
5	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
6	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
7	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
8	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
9	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
10	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
11	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
12	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
13	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
14	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
15	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
16	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
17	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
18	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
19	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
20	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
21	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
22	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
23	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
24	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
25	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
26	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
27	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
28	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
29	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
30	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
31	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
32	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
33	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
34	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
35	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
36	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
37	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
38	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
39	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
40	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
41	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
42	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
43	16418842	Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.
44	16418842	To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis.
45	16418842	A Western blot analysis for nestin, vimentin, and desmin demonstrated their exclusive expression in glomeruli and showed their increase in expression in nephrotic glomeruli.
46	16418842	Immunolocalization studies showed nestin and vimentin to be located predominantly in the podocytes in both normal and nephrotic glomeruli and that enhancement of desmin staining only occurred in podocytes.
47	16418842	A ribonuclease protection assay showed high levels of vimentin and nestin expression in normal glomeruli and an upregulation of all three IF transcripts in nephrotic glomeruli.
48	16418842	One day after the PAN injection, however, the vimentin transcripts were found to already have significantly increased, whereas those of nestin or desmin showed no such increase.
49	16418842	These findings indicate that podocytes express three IF proteins, namely, vimentin, desmin, and nestin, which are differentially regulated in response to injury.
50	16571784	Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes.
51	16571784	Nestin, an intermediate filament protein, is widely used as stem cell marker.
52	16571784	The nestin-positive structures also were labeled by endothelial cell markers FLK1 and CD31 in immature glomeruli.
53	16571784	In contrast, in mature glomerular, nestin immunoreactivity was observed only outside laminin-positive glomerular basement membrane, and co-localized with nephrin, consistent with podocyte nestin expression.
54	16571784	Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes.
55	16571784	Nestin, an intermediate filament protein, is widely used as stem cell marker.
56	16571784	The nestin-positive structures also were labeled by endothelial cell markers FLK1 and CD31 in immature glomeruli.
57	16571784	In contrast, in mature glomerular, nestin immunoreactivity was observed only outside laminin-positive glomerular basement membrane, and co-localized with nephrin, consistent with podocyte nestin expression.
58	16571784	Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes.
59	16571784	Nestin, an intermediate filament protein, is widely used as stem cell marker.
60	16571784	The nestin-positive structures also were labeled by endothelial cell markers FLK1 and CD31 in immature glomeruli.
61	16571784	In contrast, in mature glomerular, nestin immunoreactivity was observed only outside laminin-positive glomerular basement membrane, and co-localized with nephrin, consistent with podocyte nestin expression.
62	16571784	Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes.
63	16571784	Nestin, an intermediate filament protein, is widely used as stem cell marker.
64	16571784	The nestin-positive structures also were labeled by endothelial cell markers FLK1 and CD31 in immature glomeruli.
65	16571784	In contrast, in mature glomerular, nestin immunoreactivity was observed only outside laminin-positive glomerular basement membrane, and co-localized with nephrin, consistent with podocyte nestin expression.
66	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
67	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
68	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
69	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
70	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
71	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
72	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
73	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
74	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
75	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
76	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
77	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
78	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
79	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
80	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
81	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
82	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
83	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
84	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
85	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
86	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
87	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
88	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
89	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
90	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
91	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
92	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
93	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
94	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
95	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
96	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
97	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
98	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
99	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
100	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
101	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
102	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
103	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
104	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
105	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
106	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
107	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
108	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
109	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
110	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
111	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
112	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
113	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
114	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
115	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
116	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
117	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
118	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
119	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
120	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
121	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
122	16614054	Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.
123	16614054	Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells.
124	16614054	Nestin shared a striking overlap in expression with the Wilms' tumor suppressor Wt1.
125	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
126	16614054	Cotransfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to six-fold by the Wt1(-KTS) splice variant.
127	16614054	Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels.
128	16614054	Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable compared with the hearts of wild-type embryos.
129	16614054	Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1.
130	17210924	We investigated nestin expression in human adult and fetal kidney as well as CDK5 presence in adult human podocytes.
131	17210924	Confocal microscopy demonstrated that adult glomeruli display nestin immunoreactivity in vimentin-expressing cells with the podocyte morphology and not in cells bearing the endothelial marker CD31.
132	17210924	Glomerular nestin-positive cells were CDK5 immunoreactive as well.
133	17210924	Similar experiments carried out with antibodies raised against nestin and alpha-smooth muscle actin showed that the first mesangial cells that populate the developing glomeruli expressed nestin.
134	17210924	We investigated nestin expression in human adult and fetal kidney as well as CDK5 presence in adult human podocytes.
135	17210924	Confocal microscopy demonstrated that adult glomeruli display nestin immunoreactivity in vimentin-expressing cells with the podocyte morphology and not in cells bearing the endothelial marker CD31.
136	17210924	Glomerular nestin-positive cells were CDK5 immunoreactive as well.
137	17210924	Similar experiments carried out with antibodies raised against nestin and alpha-smooth muscle actin showed that the first mesangial cells that populate the developing glomeruli expressed nestin.
138	17210924	We investigated nestin expression in human adult and fetal kidney as well as CDK5 presence in adult human podocytes.
139	17210924	Confocal microscopy demonstrated that adult glomeruli display nestin immunoreactivity in vimentin-expressing cells with the podocyte morphology and not in cells bearing the endothelial marker CD31.
140	17210924	Glomerular nestin-positive cells were CDK5 immunoreactive as well.
141	17210924	Similar experiments carried out with antibodies raised against nestin and alpha-smooth muscle actin showed that the first mesangial cells that populate the developing glomeruli expressed nestin.
142	17210924	We investigated nestin expression in human adult and fetal kidney as well as CDK5 presence in adult human podocytes.
143	17210924	Confocal microscopy demonstrated that adult glomeruli display nestin immunoreactivity in vimentin-expressing cells with the podocyte morphology and not in cells bearing the endothelial marker CD31.
144	17210924	Glomerular nestin-positive cells were CDK5 immunoreactive as well.
145	17210924	Similar experiments carried out with antibodies raised against nestin and alpha-smooth muscle actin showed that the first mesangial cells that populate the developing glomeruli expressed nestin.
146	17255215	The present study characterizes the expression of nestin, an intermediate filament protein, in human kidneys.
147	17255215	Nestin also colocalized with vimentin in the periphery of capillary loops but not in the mesangium.
148	17255215	Semiquantitative analysis of immunostaining showed that glomerular nestin expression in IgA nephropathy without proteinuria was not different from normal kidney; however, nestin expression in kidneys of patients with IgA nephropathy and proteinuria, or MN and FSGS with proteinuria was significantly reduced compared with normal kidney (P < 0.01).
149	17255215	Reduced nestin mRNA expression in the patients with IgA nephropathy with proteinuria and FSGN was also observed by quantitative real-time PCR.
150	17255215	The present study characterizes the expression of nestin, an intermediate filament protein, in human kidneys.
151	17255215	Nestin also colocalized with vimentin in the periphery of capillary loops but not in the mesangium.
152	17255215	Semiquantitative analysis of immunostaining showed that glomerular nestin expression in IgA nephropathy without proteinuria was not different from normal kidney; however, nestin expression in kidneys of patients with IgA nephropathy and proteinuria, or MN and FSGS with proteinuria was significantly reduced compared with normal kidney (P < 0.01).
153	17255215	Reduced nestin mRNA expression in the patients with IgA nephropathy with proteinuria and FSGN was also observed by quantitative real-time PCR.
154	17255215	The present study characterizes the expression of nestin, an intermediate filament protein, in human kidneys.
155	17255215	Nestin also colocalized with vimentin in the periphery of capillary loops but not in the mesangium.
156	17255215	Semiquantitative analysis of immunostaining showed that glomerular nestin expression in IgA nephropathy without proteinuria was not different from normal kidney; however, nestin expression in kidneys of patients with IgA nephropathy and proteinuria, or MN and FSGS with proteinuria was significantly reduced compared with normal kidney (P < 0.01).
157	17255215	Reduced nestin mRNA expression in the patients with IgA nephropathy with proteinuria and FSGN was also observed by quantitative real-time PCR.
158	17255215	The present study characterizes the expression of nestin, an intermediate filament protein, in human kidneys.
159	17255215	Nestin also colocalized with vimentin in the periphery of capillary loops but not in the mesangium.
160	17255215	Semiquantitative analysis of immunostaining showed that glomerular nestin expression in IgA nephropathy without proteinuria was not different from normal kidney; however, nestin expression in kidneys of patients with IgA nephropathy and proteinuria, or MN and FSGS with proteinuria was significantly reduced compared with normal kidney (P < 0.01).
161	17255215	Reduced nestin mRNA expression in the patients with IgA nephropathy with proteinuria and FSGN was also observed by quantitative real-time PCR.
162	17637254	Time course of expression of intermediate filament protein vimentin, nestin and desmin in rat renal glomerular injury.
163	17784648	Co-expression of nestin and vimentin was observed in mature rat podocytes.
164	17929992	Nestin co-localized with vimentin but not with actin or heavy chain myosin IIA, using a mouse podocyte cell line.
165	17929992	Knockdown of nestin in a murine podocyte cell line failed to produce any obvious phenotypic change or alteration in vimentin distribution but was associated with increased cell cycling.
166	17929992	Perhaps through an association with vimentin, nestin serves to bolster the mechanical strength of these cells that experience high tensile stress during glomerular filtration.
167	17929992	Nestin co-localized with vimentin but not with actin or heavy chain myosin IIA, using a mouse podocyte cell line.
168	17929992	Knockdown of nestin in a murine podocyte cell line failed to produce any obvious phenotypic change or alteration in vimentin distribution but was associated with increased cell cycling.
169	17929992	Perhaps through an association with vimentin, nestin serves to bolster the mechanical strength of these cells that experience high tensile stress during glomerular filtration.
170	17929992	Nestin co-localized with vimentin but not with actin or heavy chain myosin IIA, using a mouse podocyte cell line.
171	17929992	Knockdown of nestin in a murine podocyte cell line failed to produce any obvious phenotypic change or alteration in vimentin distribution but was associated with increased cell cycling.
172	17929992	Perhaps through an association with vimentin, nestin serves to bolster the mechanical strength of these cells that experience high tensile stress during glomerular filtration.
173	18199804	We reasoned that the intermediate filament protein nestin, a marker of progenitor cells that has recently been identified in podocytes, may allow the investigation of podocyte involvement in glomerular crescents.
174	18199804	CD68-positive cells were observed in 80% of cases but were never as numerous as the nestin-positive cells.
175	18199804	Nestin and CD68 were not coexpressed by the same cells, providing no evidence of trans-differentiation of podocytes into a macrophage phenotype.
176	18199804	Up to one third of crescent cells were cycling in 48% of biopsies, and double immunostaining identified these cells as a mixture of nestin-positive cells and "null" cells (negative for nestin, CD68, and keratin).
177	18199804	We reasoned that the intermediate filament protein nestin, a marker of progenitor cells that has recently been identified in podocytes, may allow the investigation of podocyte involvement in glomerular crescents.
178	18199804	CD68-positive cells were observed in 80% of cases but were never as numerous as the nestin-positive cells.
179	18199804	Nestin and CD68 were not coexpressed by the same cells, providing no evidence of trans-differentiation of podocytes into a macrophage phenotype.
180	18199804	Up to one third of crescent cells were cycling in 48% of biopsies, and double immunostaining identified these cells as a mixture of nestin-positive cells and "null" cells (negative for nestin, CD68, and keratin).
181	18199804	We reasoned that the intermediate filament protein nestin, a marker of progenitor cells that has recently been identified in podocytes, may allow the investigation of podocyte involvement in glomerular crescents.
182	18199804	CD68-positive cells were observed in 80% of cases but were never as numerous as the nestin-positive cells.
183	18199804	Nestin and CD68 were not coexpressed by the same cells, providing no evidence of trans-differentiation of podocytes into a macrophage phenotype.
184	18199804	Up to one third of crescent cells were cycling in 48% of biopsies, and double immunostaining identified these cells as a mixture of nestin-positive cells and "null" cells (negative for nestin, CD68, and keratin).
185	18199804	We reasoned that the intermediate filament protein nestin, a marker of progenitor cells that has recently been identified in podocytes, may allow the investigation of podocyte involvement in glomerular crescents.
186	18199804	CD68-positive cells were observed in 80% of cases but were never as numerous as the nestin-positive cells.
187	18199804	Nestin and CD68 were not coexpressed by the same cells, providing no evidence of trans-differentiation of podocytes into a macrophage phenotype.
188	18199804	Up to one third of crescent cells were cycling in 48% of biopsies, and double immunostaining identified these cells as a mixture of nestin-positive cells and "null" cells (negative for nestin, CD68, and keratin).
189	18268475	We investigated whether the intermediate filament protein and neural stem cell marker nestin characterizes the glomerular progenitor/reserve cell population immigrating the glomerulus after mesangial cell (MC) injury in the rat (anti-Thy1 nephritis).
190	18268475	At the peak of mesangial proliferation and expansion (day 5) most OX-7-positive MCs expressed nestin largely colocalizing with the activation marker alpha-smooth muscle actin and the proliferation marker PCNA.
191	18268475	We investigated whether the intermediate filament protein and neural stem cell marker nestin characterizes the glomerular progenitor/reserve cell population immigrating the glomerulus after mesangial cell (MC) injury in the rat (anti-Thy1 nephritis).
192	18268475	At the peak of mesangial proliferation and expansion (day 5) most OX-7-positive MCs expressed nestin largely colocalizing with the activation marker alpha-smooth muscle actin and the proliferation marker PCNA.
193	18776121	Glomerular labeling of ezrin, moesin, and gelsolin was altered at 3 wk, but expression of nestin and alpha-actinin was unchanged.
194	18776121	In contrast, expression of glomerular endothelial and mesangial cell miRNAs (miR-126 and miR-145, respectively) was unchanged.
195	19241870	[Intermediate filament proteins nestin and vimentin in the rat kidney cells].
196	19241870	The data on the presence of the kidney cells can contain neuroglial markers (nestin, vimentin, glial fibrillar acidic protein--GFAP) appeared unexpected and require a detailed investigation.
197	19241870	It was demonstrated that the renal corpuscle contained both nestin- and vimentin-immunopositive cells (podocytes).
198	19241870	Thus, the combination of nestin and vimentin was found to be typical for adult rat kidney podocytes.
199	19241870	[Intermediate filament proteins nestin and vimentin in the rat kidney cells].
200	19241870	The data on the presence of the kidney cells can contain neuroglial markers (nestin, vimentin, glial fibrillar acidic protein--GFAP) appeared unexpected and require a detailed investigation.
201	19241870	It was demonstrated that the renal corpuscle contained both nestin- and vimentin-immunopositive cells (podocytes).
202	19241870	Thus, the combination of nestin and vimentin was found to be typical for adult rat kidney podocytes.
203	19241870	[Intermediate filament proteins nestin and vimentin in the rat kidney cells].
204	19241870	The data on the presence of the kidney cells can contain neuroglial markers (nestin, vimentin, glial fibrillar acidic protein--GFAP) appeared unexpected and require a detailed investigation.
205	19241870	It was demonstrated that the renal corpuscle contained both nestin- and vimentin-immunopositive cells (podocytes).
206	19241870	Thus, the combination of nestin and vimentin was found to be typical for adult rat kidney podocytes.
207	19241870	[Intermediate filament proteins nestin and vimentin in the rat kidney cells].
208	19241870	The data on the presence of the kidney cells can contain neuroglial markers (nestin, vimentin, glial fibrillar acidic protein--GFAP) appeared unexpected and require a detailed investigation.
209	19241870	It was demonstrated that the renal corpuscle contained both nestin- and vimentin-immunopositive cells (podocytes).
210	19241870	Thus, the combination of nestin and vimentin was found to be typical for adult rat kidney podocytes.
211	19581826	Immunohistochemistry provided a profile of podocyte differentiation with metanephric mesenchyme and developing podocytes nestin positive and synaptopodin negative, whereas mature podocytes were positive for both markers.
212	19581826	Further investigation of individual components of ECM (laminin, fibronectin, collagen I, or collagen IV) indicated that collagen I supported the greatest proliferation similar to renal ECM, whereas a greater number of mature podocytes (nestin+/synaptopodin+) were observed on fibronectin.
213	19581826	These results suggest that (1) culture of fetal monkey podocytes can be accomplished, (2) renal ECM and collagen I can support renal cortical cells in vitro, which may recapitulate the developing kidney in vivo, and (3) fibronectin can support podocyte differentiation in vitro.
214	19581826	Immunohistochemistry provided a profile of podocyte differentiation with metanephric mesenchyme and developing podocytes nestin positive and synaptopodin negative, whereas mature podocytes were positive for both markers.
215	19581826	Further investigation of individual components of ECM (laminin, fibronectin, collagen I, or collagen IV) indicated that collagen I supported the greatest proliferation similar to renal ECM, whereas a greater number of mature podocytes (nestin+/synaptopodin+) were observed on fibronectin.
216	19581826	These results suggest that (1) culture of fetal monkey podocytes can be accomplished, (2) renal ECM and collagen I can support renal cortical cells in vitro, which may recapitulate the developing kidney in vivo, and (3) fibronectin can support podocyte differentiation in vitro.
217	19875807	In this study, we used confocal microscopy, laser capture microdissection, and real-time quantitative reverse transcriptase-PCR to demonstrate that hypercellular lesions of different podocytopathies and crescentic glomerulonephritis consist of three distinct populations: CD133(+)CD24(+)podocalyxin (PDX)(-)nestin(-) renal progenitors, CD133(+)CD24(+)PDX(+)nestin(+) transitional cells, and CD133(-)CD24(-)PDX(+)nestin(+) differentiated podocytes.
218	19875807	In addition, TGF-beta induced CD133(+)CD24(+) progenitors to produce extracellular matrix, and these were the only cells to express the proliferation marker Ki67.
219	19955187	Characterization of arbitrarily selected two clonal cell lines from each human subject was carried out. mRNA expression for the podocyte markers synaptopodin, nestin, and CD2AP were detected in all eight clones.
220	19955187	The expression of nephrin, Wilms' tumor 1 (WT1), and podocalyxin mRNA varied among the clones, which may be due to transformation and/or cloning.
221	20495534	Immunohistochemistry was applied to detect the expression of nestin, cell-cycle regulatory protein p27, as well as complement C5b-9 and complement receptor 1 (CR1).
222	20495534	Compared with the Control, IgAN glomeruli had reduced podocyte expression of p27 and nestin along with decreased podocyte number.
223	20495534	Immunohistochemistry was applied to detect the expression of nestin, cell-cycle regulatory protein p27, as well as complement C5b-9 and complement receptor 1 (CR1).
224	20495534	Compared with the Control, IgAN glomeruli had reduced podocyte expression of p27 and nestin along with decreased podocyte number.
225	20518888	Sections were immunostained for nestin, alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, CD34, and other stromal markers.
226	20518888	Interestingly, we observed a concomitant appearance of nestin- and CD34-positive myofibroblasts under fibrosing conditions.
227	20518888	Sections were immunostained for nestin, alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, CD34, and other stromal markers.
228	20518888	Interestingly, we observed a concomitant appearance of nestin- and CD34-positive myofibroblasts under fibrosing conditions.
229	20634963	CDKN1, DAG1, DDN, EHD3, MYH9, NES, NPHS1, NPHS2, PDPN, PLA2R1, PLCE1, PODXL, PTPRO, SYNPO, TCF21, TJP1, WT1).
230	20634963	This finding was further validated by assessing the expression of the axon guidance molecules neuritin (NRN1) and roundabout receptor ROBO1 and -2.
231	20818613	To identify morphological and developmental changes in protein and RNA expression patterns during nephrogenesis, immunohistochemistry and quantitative real-time PCR were used to assess temporal and spatial expression of WT1, Pax2, Nestin, Synaptopodin, alpha-smooth muscle actin (α-SMA), CD31, vascular endothelial growth factor (VEGF), and Gremlin.
232	20818613	Mature podocytes expressing WT1, Nestin, and Synaptopodin were observed from the mid-third trimester through adulthood.
233	20818613	The developing glomerulus was positive for α-SMA (vascular smooth muscle) and Gremlin (mesangial cells), CD31 (glomerular endothelium), and VEGF (endothelium), and showed loss of expression of these markers as glomerular maturation was completed.
234	20818613	To identify morphological and developmental changes in protein and RNA expression patterns during nephrogenesis, immunohistochemistry and quantitative real-time PCR were used to assess temporal and spatial expression of WT1, Pax2, Nestin, Synaptopodin, alpha-smooth muscle actin (α-SMA), CD31, vascular endothelial growth factor (VEGF), and Gremlin.
235	20818613	Mature podocytes expressing WT1, Nestin, and Synaptopodin were observed from the mid-third trimester through adulthood.
236	20818613	The developing glomerulus was positive for α-SMA (vascular smooth muscle) and Gremlin (mesangial cells), CD31 (glomerular endothelium), and VEGF (endothelium), and showed loss of expression of these markers as glomerular maturation was completed.
237	22614921	Considering that nestin is a substrate of cyclin-dependent kinase 5 (Cdk5), we further assessed the expression of Cdk5 in HG-treated podocytes.
238	22614921	The protein activator of Cdk5, p35, was also increased in a time-dependent manner by HG stimulation, and downregulation of Cdk5 by miRNA interference attenuated the nestin reduction in HG-treated podocytes; the HG-induced podocyte apoptosis, the increased cleaved caspase-3 expression and the Bax/Bcl-2 ratio were all effectively attenuated.
239	22614921	These data suggested that nestin, which is dependent on Cdk5 regulation, plays a cytoprotective role in HG-induced podocyte apoptosis.
240	22614921	Considering that nestin is a substrate of cyclin-dependent kinase 5 (Cdk5), we further assessed the expression of Cdk5 in HG-treated podocytes.
241	22614921	The protein activator of Cdk5, p35, was also increased in a time-dependent manner by HG stimulation, and downregulation of Cdk5 by miRNA interference attenuated the nestin reduction in HG-treated podocytes; the HG-induced podocyte apoptosis, the increased cleaved caspase-3 expression and the Bax/Bcl-2 ratio were all effectively attenuated.
242	22614921	These data suggested that nestin, which is dependent on Cdk5 regulation, plays a cytoprotective role in HG-induced podocyte apoptosis.
243	22614921	Considering that nestin is a substrate of cyclin-dependent kinase 5 (Cdk5), we further assessed the expression of Cdk5 in HG-treated podocytes.
244	22614921	The protein activator of Cdk5, p35, was also increased in a time-dependent manner by HG stimulation, and downregulation of Cdk5 by miRNA interference attenuated the nestin reduction in HG-treated podocytes; the HG-induced podocyte apoptosis, the increased cleaved caspase-3 expression and the Bax/Bcl-2 ratio were all effectively attenuated.
245	22614921	These data suggested that nestin, which is dependent on Cdk5 regulation, plays a cytoprotective role in HG-induced podocyte apoptosis.
246	23000950	The expression of intermediate filament protein nestin and its association with cyclin-dependent kinase 5 in the glomeruli of rats with diabetic nephropathy.
247	24154691	Using a podocyte-specific injury model of FSGS carrying a genetic podocyte tag combined with double immunostaining by different sets of podocytes and parietal epithelial cell (PEC) markers [nestin/Pax8, Wilms' tumor-1 (WT1)/claudin1, and podocalyxin/Pax2], we investigated the direction of epithelial phenotypic transition and its role in FSGS.
248	24154691	In addition, the average numbers of double-positive cells for X-gal/Pax8, nestin/Pax8 and podocalyxin/Pax2 staining in the FSGS mice were comparable, whereas those of WT1/claudin1 were significantly increased.
249	24154691	Using a podocyte-specific injury model of FSGS carrying a genetic podocyte tag combined with double immunostaining by different sets of podocytes and parietal epithelial cell (PEC) markers [nestin/Pax8, Wilms' tumor-1 (WT1)/claudin1, and podocalyxin/Pax2], we investigated the direction of epithelial phenotypic transition and its role in FSGS.
250	24154691	In addition, the average numbers of double-positive cells for X-gal/Pax8, nestin/Pax8 and podocalyxin/Pax2 staining in the FSGS mice were comparable, whereas those of WT1/claudin1 were significantly increased.
251	24699703	Studies have shown that some mature proteins of podocytes, such as podocin, nephrin, and synaptopodin, were also expressed in neurons.
252	24699703	We further inhibited the expression of Neuron-specific enolase, nestin, synaptopodin and Ubiquitin carboxy terminal hydrolase-1 by Small interfering RNA in cultured mouse podocytes and observed the significant morphological changes in treated podocytes.
253	24699703	When podocytes were treated with Adriamycin, the protein expression of Neuron-specific enolase, nestin, synaptopodin and Ubiquitin carboxy terminal hydrolase-1 decreased over time.
254	24699703	Studies have shown that some mature proteins of podocytes, such as podocin, nephrin, and synaptopodin, were also expressed in neurons.
255	24699703	We further inhibited the expression of Neuron-specific enolase, nestin, synaptopodin and Ubiquitin carboxy terminal hydrolase-1 by Small interfering RNA in cultured mouse podocytes and observed the significant morphological changes in treated podocytes.
256	24699703	When podocytes were treated with Adriamycin, the protein expression of Neuron-specific enolase, nestin, synaptopodin and Ubiquitin carboxy terminal hydrolase-1 decreased over time.
257	25736496	These isolated Nestin(+) cells expressed the typical cell-surface marker of MSC, including Sca-1, CD44, CD106, NG2 and PDGFR-α.
258	26795482	Studying Nestin and its Interrelationship with Cdk5.
259	26795482	In this review, the broad and similar roles of IFs as dynamic signaling scaffolds, is exemplified by observations of nestin functions and its interaction with the cyclin- dependent kinase 5, the atypical kinase in the family of cyclin-dependent kinases.
260	26795482	Studying Nestin and its Interrelationship with Cdk5.
261	26795482	In this review, the broad and similar roles of IFs as dynamic signaling scaffolds, is exemplified by observations of nestin functions and its interaction with the cyclin- dependent kinase 5, the atypical kinase in the family of cyclin-dependent kinases.
262	27695940	Both MET and EMT processes involve changes in content and organization of cytoskeletal and actin filaments, accompanied by the increased glomerular vascularization.
263	27695940	Here, we analyze and compare normal human developing, postnatal and nephrotic podocytes and glomeruli, using immunohistochemical and double immunofluorescent methods for detection of markers of cytoskeletal filaments (nestin, cytokeratin 10-CK10, vimentin and α-SMA), vasculogenesis (CD31 and VEGF) and podocyte function (receptor for advanced glycation end products, RAGE).
264	27695940	In differentiating podocytes and cells of Bowman's capsule (parietal podocytes) nestin decreases, vimentin increases, while CK10 gradually disappears.
265	27695940	Both MET and EMT processes involve changes in content and organization of cytoskeletal and actin filaments, accompanied by the increased glomerular vascularization.
266	27695940	Here, we analyze and compare normal human developing, postnatal and nephrotic podocytes and glomeruli, using immunohistochemical and double immunofluorescent methods for detection of markers of cytoskeletal filaments (nestin, cytokeratin 10-CK10, vimentin and α-SMA), vasculogenesis (CD31 and VEGF) and podocyte function (receptor for advanced glycation end products, RAGE).
267	27695940	In differentiating podocytes and cells of Bowman's capsule (parietal podocytes) nestin decreases, vimentin increases, while CK10 gradually disappears.
268	28148530	Unbiased transcriptome profiling and functional genomics approaches have identified ubiquitin-specific protease 40 (USP40) as a highly specific glomerular transcript.
269	28148530	USP40 in cultured glomerular endothelial cells and podocytes was specifically localized to the intermediate filament protein nestin.
270	28148530	In glomerular endothelial cells, immunoprecipitation confirmed actual protein-protein binding of USP40 with nestin, and USP40-small-interfering RNA transfection revealed significant reduction of nestin.
271	28148530	These data indicate that USP40/Usp40 is a novel protein that might play a crucial role in glomerulogenesis and the glomerular integrity after birth through the modulation of intermediate filament protein homeostasis.
272	29660398	We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM).
273	29660398	The capsular SC/TCs had a strong CD34 and partial nestin and CD105 immunopositivity.
274	29660398	Subcapsular and interstitial SC/TCs expressed c-kit, nestin, CD105, but also α-SMA and SMM, therefore having a myoid phenotype.
275	29660398	The endothelial SC/TCs phenotype was CD31+/CD34+/CD105+/nestin±/SMM±/α-SMA±.
276	29660398	In epithelial cells, we found a positive expression for CD31, CD117/c-kit, desmin, CD34, SMM, and CD105.
277	29660398	We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM).
278	29660398	The capsular SC/TCs had a strong CD34 and partial nestin and CD105 immunopositivity.
279	29660398	Subcapsular and interstitial SC/TCs expressed c-kit, nestin, CD105, but also α-SMA and SMM, therefore having a myoid phenotype.
280	29660398	The endothelial SC/TCs phenotype was CD31+/CD34+/CD105+/nestin±/SMM±/α-SMA±.
281	29660398	In epithelial cells, we found a positive expression for CD31, CD117/c-kit, desmin, CD34, SMM, and CD105.
282	29660398	We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM).
283	29660398	The capsular SC/TCs had a strong CD34 and partial nestin and CD105 immunopositivity.
284	29660398	Subcapsular and interstitial SC/TCs expressed c-kit, nestin, CD105, but also α-SMA and SMM, therefore having a myoid phenotype.
285	29660398	The endothelial SC/TCs phenotype was CD31+/CD34+/CD105+/nestin±/SMM±/α-SMA±.
286	29660398	In epithelial cells, we found a positive expression for CD31, CD117/c-kit, desmin, CD34, SMM, and CD105.
287	29660398	We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM).
288	29660398	The capsular SC/TCs had a strong CD34 and partial nestin and CD105 immunopositivity.
289	29660398	Subcapsular and interstitial SC/TCs expressed c-kit, nestin, CD105, but also α-SMA and SMM, therefore having a myoid phenotype.
290	29660398	The endothelial SC/TCs phenotype was CD31+/CD34+/CD105+/nestin±/SMM±/α-SMA±.
291	29660398	In epithelial cells, we found a positive expression for CD31, CD117/c-kit, desmin, CD34, SMM, and CD105.
292	29689548	Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5.
293	29990736	Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan.
294	29990736	The transcriptional levels of intermediate filament proteins (desmin, vimentin, nestin, and connexin 43) were assessed by using quantitative real-time polymerase chain reaction (PCR), and the cell proliferation markers (proliferating cell nuclear antigen [PCNA] and proliferation-associated nuclear antigen [Ki-67]) were recognized by immunohistochemical analysis.
295	29990736	Moreover, furan enhances the expression of PCNA and Ki-67 in the liver tissues but not in the kidney tissues.
296	29990736	Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan.
297	29990736	The transcriptional levels of intermediate filament proteins (desmin, vimentin, nestin, and connexin 43) were assessed by using quantitative real-time polymerase chain reaction (PCR), and the cell proliferation markers (proliferating cell nuclear antigen [PCNA] and proliferation-associated nuclear antigen [Ki-67]) were recognized by immunohistochemical analysis.
298	29990736	Moreover, furan enhances the expression of PCNA and Ki-67 in the liver tissues but not in the kidney tissues.
299	30132346	Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.
300	30132346	Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction.
301	30132346	After 6 mo of hyperglycemia, diabetic Diaph1^-/- mice displayed significantly reduced mesangial sclerosis, podocyte effacement, glomerular basement thickening, and urinary albumin-to-creatinine ratio compared with diabetic mice expressing Diaph1.
302	30132346	In glomerular isolates, expression of two genes linked to podocyte stress, growth arrest-specific 1 ( Gas1) and cluster of differentiation 36 ( Cd36), was significantly attenuated in diabetic Diaph1^-/- mice compared with controls, in parallel with significantly higher levels of nestin (Nes) mRNA, a podocyte marker.
303	30258943	The imPOD cells express most podocyte-related markers, including WT-1, Nephrin, Tubulin and Vinculin, but not differentiation marker Synaptopodin.
304	30258943	We further demonstrate that TGFβ1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers, α-SMA, Vimentin and Nestin, as well as fibrogenic factors CTGF and Col1a1.
305	32371936	The correlations among nestin, nephrin and proteinuria were analyzed in LN patients and MRL/lpr lupus-prone mice.
306	32371936	There was a significantly negative correlation between nestin and proteinuria both in LN patients and MRL/lpr mice, whereas the expression of nephrin was positively correlated with nestin.
307	32371936	Knockdown of nestin resulted in not only the decrease of nephrin, p-nephrin (Y1217) and mitophagy-associated proteins in cultured podocytes and the podocytes of MRL/lpr mice, but also mitochondrial dysfunction in podocytes stimulated with LN plasma.
308	32371936	Our findings suggested that nestin regulated the expression of nephrin through mitophagy and oxidative stress to protect the podocytes from injury in LN.
309	32371936	The correlations among nestin, nephrin and proteinuria were analyzed in LN patients and MRL/lpr lupus-prone mice.
310	32371936	There was a significantly negative correlation between nestin and proteinuria both in LN patients and MRL/lpr mice, whereas the expression of nephrin was positively correlated with nestin.
311	32371936	Knockdown of nestin resulted in not only the decrease of nephrin, p-nephrin (Y1217) and mitophagy-associated proteins in cultured podocytes and the podocytes of MRL/lpr mice, but also mitochondrial dysfunction in podocytes stimulated with LN plasma.
312	32371936	Our findings suggested that nestin regulated the expression of nephrin through mitophagy and oxidative stress to protect the podocytes from injury in LN.
313	32371936	The correlations among nestin, nephrin and proteinuria were analyzed in LN patients and MRL/lpr lupus-prone mice.
314	32371936	There was a significantly negative correlation between nestin and proteinuria both in LN patients and MRL/lpr mice, whereas the expression of nephrin was positively correlated with nestin.
315	32371936	Knockdown of nestin resulted in not only the decrease of nephrin, p-nephrin (Y1217) and mitophagy-associated proteins in cultured podocytes and the podocytes of MRL/lpr mice, but also mitochondrial dysfunction in podocytes stimulated with LN plasma.
316	32371936	Our findings suggested that nestin regulated the expression of nephrin through mitophagy and oxidative stress to protect the podocytes from injury in LN.
317	32371936	The correlations among nestin, nephrin and proteinuria were analyzed in LN patients and MRL/lpr lupus-prone mice.
318	32371936	There was a significantly negative correlation between nestin and proteinuria both in LN patients and MRL/lpr mice, whereas the expression of nephrin was positively correlated with nestin.
319	32371936	Knockdown of nestin resulted in not only the decrease of nephrin, p-nephrin (Y1217) and mitophagy-associated proteins in cultured podocytes and the podocytes of MRL/lpr mice, but also mitochondrial dysfunction in podocytes stimulated with LN plasma.
320	32371936	Our findings suggested that nestin regulated the expression of nephrin through mitophagy and oxidative stress to protect the podocytes from injury in LN.
321	33613972	Kidney tissues were subjected to histo-biochemical analysis along with mRNA gene expression quantification for cytoskeleton proteins encoding genes (vimentin, nestin, and connexin 43) by real-time reverse transcription polymerase chain reaction.
322	35149934	Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury.