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Gene Information
Gene symbol: NFE2
Gene name: nuclear factor (erythroid-derived 2), 45kDa
HGNC ID: 7780
Synonyms: NF-E2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NFE2L2 | 1 hits |
| 2 | USP15 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 34931430 | Inhibition of USP15 ameliorates high-glucose-induced oxidative stress and inflammatory injury in podocytes through regulation of the Keap1/Nrf2 signaling. |
| 2 | 34931430 | Ubiquitin-specific peptidase 15 (USP15) is implicated in the pathogenesis of numerous diseases. |
| 3 | 34931430 | Further investigation showed that inhibition of USP15 enhanced the activation of NF-E2-related factor 2 (Nrf2) and expression of Nrf2 target genes in HG-simulated podocytes. |
| 4 | 34931430 | Moreover, depletion of Kelch-like ECH-associated protein 1 (Keap1) diminished the regulatory effect of USP15 inhibition on Nrf2 activation. |
| 5 | 34931430 | Taken together, these data indicate that USP15 inhibition protects podocytes from HG-induced injury by enhancing Nrf2 activation via Keap1. |