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Gene Information
Gene symbol: NOTCH3
Gene name: notch 3
HGNC ID: 7883
Synonyms: CASIL
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTC1 | 1 hits |
| 2 | CD44 | 1 hits |
| 3 | COL1A1 | 1 hits |
| 4 | COL4A4 | 1 hits |
| 5 | CREB1 | 1 hits |
| 6 | CREBBP | 1 hits |
| 7 | EP300 | 1 hits |
| 8 | KLF15 | 1 hits |
| 9 | MCAM | 1 hits |
| 10 | PDGFB | 1 hits |
| 11 | PDGFRA | 1 hits |
| 12 | PDGFRB | 1 hits |
| 13 | RBPJ | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26017974 | In addition to segmental and global glomerulosclerosis in older mice, staining for matrix proteins collagen type IV and heparan sulfate proteoglycan were markedly increased in Bowman's capsules of older mouse glomeruli, consistent with increased extracellular matrix production by PECs. |
| 2 | 26017974 | The mural cell markers neural/glial antigen 2, PDGF receptor-β, and CD146 as well as Notch 3 were also substantially increased in aged PECs. |
| 3 | 27440779 | Additionally, markers of epithelial-to-mesenchymal transition (platelet-derived growth factor receptor-β, α-smooth muscle actin, Notch-3) and PEC activation (CD44, collagen IV) were further increased by mTOR reduction. |
| 4 | 34506759 | EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling. |
| 5 | 34506759 | Bioinformatics analysis revealed EP300/CBP, a transcriptional co-activator, as a central hub for the crosstalk between these two signaling pathways. |
| 6 | 34506759 | Additionally, CREB/KLF15 in cAMP-PKA pathway competed with RBP-J the major transcriptional factor of Notch3 signaling for binding to EP300/CBP. |
| 7 | 34506759 | EP300/CBP siRNA significantly inhibited these two signaling transduction pathways and disrupted the interactions between the above major transcriptional factors. |
| 8 | 34506759 | These data indicate a crucial role of EP300/CBP in regulating the crosstalk between cAMP-PKA pathway and Notch3 signaling and modulating the phenotypic change of podocytes, and enrich the reno-protective mechanisms of cAMP-PKA pathway. |
| 9 | 34506759 | EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling. |
| 10 | 34506759 | Bioinformatics analysis revealed EP300/CBP, a transcriptional co-activator, as a central hub for the crosstalk between these two signaling pathways. |
| 11 | 34506759 | Additionally, CREB/KLF15 in cAMP-PKA pathway competed with RBP-J the major transcriptional factor of Notch3 signaling for binding to EP300/CBP. |
| 12 | 34506759 | EP300/CBP siRNA significantly inhibited these two signaling transduction pathways and disrupted the interactions between the above major transcriptional factors. |
| 13 | 34506759 | These data indicate a crucial role of EP300/CBP in regulating the crosstalk between cAMP-PKA pathway and Notch3 signaling and modulating the phenotypic change of podocytes, and enrich the reno-protective mechanisms of cAMP-PKA pathway. |
| 14 | 34506759 | EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling. |
| 15 | 34506759 | Bioinformatics analysis revealed EP300/CBP, a transcriptional co-activator, as a central hub for the crosstalk between these two signaling pathways. |
| 16 | 34506759 | Additionally, CREB/KLF15 in cAMP-PKA pathway competed with RBP-J the major transcriptional factor of Notch3 signaling for binding to EP300/CBP. |
| 17 | 34506759 | EP300/CBP siRNA significantly inhibited these two signaling transduction pathways and disrupted the interactions between the above major transcriptional factors. |
| 18 | 34506759 | These data indicate a crucial role of EP300/CBP in regulating the crosstalk between cAMP-PKA pathway and Notch3 signaling and modulating the phenotypic change of podocytes, and enrich the reno-protective mechanisms of cAMP-PKA pathway. |