Ignet

Gene Information

Gene symbol: NPC1

Gene name: Niemann-Pick disease, type C1

HGNC ID: 7897

Related Genes

#	Gene Symbol	Number of hits
1	INHBE	1 hits
2	ITGA8	1 hits
3	MAPK1	1 hits
4	MAPK14	1 hits
5	PAX2	1 hits
6	PDGFRA	1 hits
7	PVRL1	1 hits
8	SALL1	1 hits
9	SIX2	1 hits
10	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	12538734	Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis.
2	12538734	The p38 mitogen-activated protein kinase (MAPK) pathway is a pro-inflammatory signal transduction pathway.
3	12538734	Immunostaining localized components of the p38 MAPK pathway (p38alpha, p-p38, p-ATF-2) in normal glomeruli, to podocytes, and occasional endothelial cells.
4	12538734	This study identified an eightfold increase in glomerular activation of p38 MAPK (phosphorylated p38, p-p38) within 3 h of the induction of rat anti-glomerular basement membrane (GBM) glomerulonephritis and localized p-p38 and p-ATF-2 to infiltrating neutrophils, with increased staining of podocytes and endothelial cells.
5	12538734	In rats, administration of a specific p38 MAPK inhibitor, NPC 31145, before induction of anti-GBM disease prevented a loss of renal function and substantially reduced proteinuria.
6	12538734	In summary, this study has localized the components of the p38 MAPK pathway to cells in normal and diseased rat and human kidney and identified a number of important mechanisms by which signaling through the p38 MAPK pathway induces inflammatory renal disease.
7	26458176	By recapitulating metanephric kidney development in vitro, we generate SIX2+ SALL1+ WT1+ PAX2+ NPCs with 90% efficiency within 9 days of differentiation.
8	29611334	The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump V-ATPase.
9	29611334	Previously, we demonstrated that conditional ablation of the PRR in Six2⁺ NPCs in mice (Six2^PRR^-/- ) causes early neonatal death.
10	29611334	Here, we identified genes that are regulated by PRR in Six2⁺ NPCs FACS-isolated from Six2^PRR^-/- and control kidneys on embryonic day E15.5 using whole-genome expression analysis.
11	29611334	Seven genes with expression in CM cells previously shown to direct kidney development, including Notch1, β-catenin, Lef1, Lhx1, Jag1, and p53, were downregulated.
12	29611334	Double-transgenic Six2^PRR^-/- /BatGal⁺ mice, a reporter strain for β-catenin transcriptional activity, showed decreased β-catenin activity in the UB in vivo.
13	29611334	Reduced PRR gene dosage in heterozygous Six2^PRR^+/- mice was associated with decreased glomerular number, segmental thickening of the glomerular basement membrane with focal podocyte foot process effacement, development of hypertension and increased soluble PRR (sPRR) levels in the urine at 2 months of age.
14	29611334	Together, these data demonstrate that NPC PRR performs essential functions during nephrogenesis via control of hierarchy of genes that regulate critical cellular processes.
15	29611334	Both reduced nephron endowment and augmented urine sPRR likely contribute to programming of hypertension in Six2^PRR^+/- mice.
16	31378669	Here we reveal that activin has superior effects to BMP7 on maintenance efficiency of human iPSC-derived NPCs.
17	31378669	Activin expanded ITGA8⁺/PDGFRA^-/SIX2-GFP⁺ NPCs by 5-fold per week at 80%-90% efficiency, and the propagated cells possessed robust capacity for nephron formation both in vitro and in vivo.
18	31378669	Here we reveal that activin has superior effects to BMP7 on maintenance efficiency of human iPSC-derived NPCs.
19	31378669	Activin expanded ITGA8⁺/PDGFRA^-/SIX2-GFP⁺ NPCs by 5-fold per week at 80%-90% efficiency, and the propagated cells possessed robust capacity for nephron formation both in vitro and in vivo.