Ignet

Gene Information

Gene symbol: NTF3

Gene name: neurotrophin 3

HGNC ID: 8023

Synonyms: NGF2

Related Genes

#	Gene Symbol	Number of hits
1	NGF	1 hits
2	NTRK1	1 hits
3	NTRK3	1 hits
4	PTPRO	1 hits

Related Sentences

#	PMID	Sentence
1	12532410	Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.
2	12532410	We studied the expression of mouse PTPRO, a type III RPTP with an extracellular region containing eight fibronectin type III domains, during embryogenesis and after birth.
3	12532410	Mouse PTPRO mRNA was observed in neuron populations expressing TrkA, the high-affinity nerve growth factor receptor, or TrkC, the neurotrophin-3 receptor, and immunoreactive mPTPRO and TrkC colocalized in large dorsal root ganglia proprioceptive neurons.
4	12532410	Our results suggest that mPTPRO is involved in the differentiation and axonogenesis of central and peripheral nervous system neurons, where it is in a position to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor.
5	12532410	Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.
6	12532410	We studied the expression of mouse PTPRO, a type III RPTP with an extracellular region containing eight fibronectin type III domains, during embryogenesis and after birth.
7	12532410	Mouse PTPRO mRNA was observed in neuron populations expressing TrkA, the high-affinity nerve growth factor receptor, or TrkC, the neurotrophin-3 receptor, and immunoreactive mPTPRO and TrkC colocalized in large dorsal root ganglia proprioceptive neurons.
8	12532410	Our results suggest that mPTPRO is involved in the differentiation and axonogenesis of central and peripheral nervous system neurons, where it is in a position to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor.
9	12532410	Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.
10	12532410	We studied the expression of mouse PTPRO, a type III RPTP with an extracellular region containing eight fibronectin type III domains, during embryogenesis and after birth.
11	12532410	Mouse PTPRO mRNA was observed in neuron populations expressing TrkA, the high-affinity nerve growth factor receptor, or TrkC, the neurotrophin-3 receptor, and immunoreactive mPTPRO and TrkC colocalized in large dorsal root ganglia proprioceptive neurons.
12	12532410	Our results suggest that mPTPRO is involved in the differentiation and axonogenesis of central and peripheral nervous system neurons, where it is in a position to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor.
13	29162704	Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation.
14	29162704	Activation of endogenous TrkC by its ligand neurotrophin-3 resulted in increased podocyte migration-a surrogate of podocyte actin dynamics in vivo.
15	29162704	Employing a mutagenesis approach, we found that the Src homologous and collagen-like (Shc) binding site Tyr⁵¹⁶ within the TrkC cytoplasmic domain was necessary for TrkC-induced migration of podocytes.
16	29162704	TrkC activation led to a mobility shift of Wiskott-Aldrich syndrome family verprolin-homologous protein (WAVE)-2 which is known to orchestrate Arp2/3 activation and actin polymerization.
17	29162704	Chemical inactivation of Erk or mutagenesis of 2 of 4 known Erk target sites within WAVE2, Thr³⁴⁶ and Ser³⁵¹, abolished the TrkC-induced WAVE2 mobility shift.
18	29162704	Knockdown of WAVE2 by shRNA abolished TrkC-induced podocyte migration.
19	29162704	In summary, TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently.