About

Home

Introduction

Statistics

Programs

Dignet

Gene

GenePair

BioSummarAI

Help & Docs

Documents

Help

FAQs

Links

Acknowledge

Disclaimer

Contact Us

Gene Information

Gene symbol: PDHB

Gene name: pyruvate dehydrogenase (lipoamide) beta

HGNC ID: 8808

Related Genes

#	Gene Symbol	Number of hits
1	MARCH8	1 hits
2	MIRN15B	1 hits
3	PDK4	1 hits
4	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	34806156	microRNA-15b-5p shuttled by mesenchymal stem cell-derived extracellular vesicles protects podocytes from diabetic nephropathy via downregulation of VEGF/PDK4 axis.
2	34806156	In the current study, we determined the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing microRNA (miR)-15b-5p in DN.
3	34806156	After extraction and identification of MSC-derived EVs, mouse podocyte line MPC5 was selected to establish an in vitro high-glucose (HG) cell model, where expression of miR-15b-5p, pyruvate dehydrogenase kinase 4 (PDK4) and VEGFA expression in tissues and cells were determined.
4	34806156	The loss- and gain- function assays were conducted to determine the roles of miR-15b-5p, PDK4 and VEGFA.
5	34806156	The binding relationship between miR-15b-5p and PDK43 by dual luciferase reporter gene assay.
6	34806156	The expression of miR-15b-5p was downregulated in podocytes under HG environment, but highly expressed in mouse MSCs-derived EVs.
7	34806156	EVs-derived miR-15b-5p could protect MPC5 cell apoptosis and inflammation. miR-15b-5p inhibited the expression of PDK4 by directly bound to the 3'UTR region of PDK4 gene. miR-15b-5p inhibits VEGF expression by binding to PDK4.
8	34806156	Inhibition of PDK4 decreased VEGFA expression and reduced apoptosis and inflammation.
9	34806156	Collectively, miR-15b-5p shuttled by MSC-derived EV can play protective roles in HG-induced mouse podocyte injury, possibly by targeting PDK4 and decreasing the VEGFA expression.