Ignet

Gene Information

Gene symbol: PI3

Gene name: peptidase inhibitor 3, skin-derived

HGNC ID: 8947

Synonyms: ESI, SKALP, ELAFIN, WAP3, WFDC14, cementoin

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	IRS1	1 hits
3	MAPK1	1 hits
4	NPHS1	1 hits
5	PIK3CG	1 hits
6	SMAD3	1 hits

Related Sentences

#	PMID	Sentence
1	22534961	Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.
2	22534961	Renal Akt was phosphorylated in adriamycin-treated mice, suggesting PI3-kinase activation.
3	22534961	Expression of mRNA for the p110γ isozyme of PI3-kinase was specifically increased and p110γ colocalized with nephrin by immunohistochemistry early in disease.
4	22534961	Thus, PI3-kinase p110γ mediates initial podocyte injury and proteinuria, both of which precede TGF-β-mediated glomerular scarring.
5	22534961	Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.
6	22534961	Renal Akt was phosphorylated in adriamycin-treated mice, suggesting PI3-kinase activation.
7	22534961	Expression of mRNA for the p110γ isozyme of PI3-kinase was specifically increased and p110γ colocalized with nephrin by immunohistochemistry early in disease.
8	22534961	Thus, PI3-kinase p110γ mediates initial podocyte injury and proteinuria, both of which precede TGF-β-mediated glomerular scarring.
9	22534961	Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.
10	22534961	Renal Akt was phosphorylated in adriamycin-treated mice, suggesting PI3-kinase activation.
11	22534961	Expression of mRNA for the p110γ isozyme of PI3-kinase was specifically increased and p110γ colocalized with nephrin by immunohistochemistry early in disease.
12	22534961	Thus, PI3-kinase p110γ mediates initial podocyte injury and proteinuria, both of which precede TGF-β-mediated glomerular scarring.
13	22534961	Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.
14	22534961	Renal Akt was phosphorylated in adriamycin-treated mice, suggesting PI3-kinase activation.
15	22534961	Expression of mRNA for the p110γ isozyme of PI3-kinase was specifically increased and p110γ colocalized with nephrin by immunohistochemistry early in disease.
16	22534961	Thus, PI3-kinase p110γ mediates initial podocyte injury and proteinuria, both of which precede TGF-β-mediated glomerular scarring.
17	24804854	Their main mechanism of action is the inhibition of cell signaling through the PI3 K/Akt/mTOR pathway.
18	25448064	We report that in mouse islet β-cells and the mouse pancreatic beta-cell line (βTC-6 cells) nephrin is associated and partly co-localized with PI3-kinase.
19	25448064	Incubation of cells with functional anti-nephrin antibodies induced nephrin clustering at the plasma membrane, nephrin phosphorylation and recruitment of PI3-kinase to nephrin thus resulting in increased PI3K-dependent Akt phosphorylation and augmented phosphorylation/inhibition of pro-apoptotic Bad and FoxO.
20	25448064	Nephrin silencing abolished Akt activation and increased susceptibility of cells to apoptosis.
21	25448064	Interestingly, a marked decrease in nephrin expression and phosphorylated Akt was observed in pancreatic islets of db/db lepr-/- diabetic mice.
22	31090283	The major signaling pathways of IR include insulin receptor substrate 1(IRS1)/phosphatidylinositiol-3-kinase(PI3 K)/serine-threonine kinase(Akt)pathway, mitogen-activated protein kinase(MAPK)pathway and Smad3 pathway.
23	34581052	At the end of the 6 th week of drug administration, all the rats were sacrificed for collecting urine, blood, and kidney tissue, followed by the examination of rat general conditions, urine and blood biochemical indicators, glomerulosclerosis-related indicators, podocyte pyroptosis markers, insulin resistance(IR)-related indicators, and key molecules in the insulin receptor substrate(IRS) 1/phosphatidylinositol-3-kinase(PI3 K)/serine threonine kinase(Akt) signaling pathway.
24	34581052	Besides, they ameliorated the expression characteristics and levels of podocyte pyroptosis markers, alleviated IR, and up-regulated the protein expression levels of the key molecules in IRS1/PI3 K/Akt pathway to varying degrees.