Ignet

Gene Information

Gene symbol: PIP5K3

Gene name: phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

HGNC ID: 23785

Related Genes

#	Gene Symbol	Number of hits
1	FIG4	1 hits
2	PIK3C3	1 hits
3	PIK3CA	1 hits
4	VAC14	1 hits

Related Sentences

#	PMID	Sentence
1	25619930	Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of the eight mammalian PI3Ks, is presumed as a main candidate.
2	25619930	To clarify the mechanism of Vps34 KO-triggered vacuolation and the PtdIns3P source for PIKfyve functionality, here we have characterized a podocyte cell type derived from Vps34fl/fl mice, which, upon Cre-mediated gene KO, robustly formed cytoplasmic vacuoles resembling those in PikfyveKO MEFs.
3	25619930	Analyses of phosphoinositide profiles by HPLC and localization patterns by a PtdIns3P biosensor revealed that Vps34 is the main supplier of localized PtdIns3P not only for PIKfyve activity but also for membrane recruitment.
4	25619930	We further revealed a plausible physiologically-relevant Vps34-independent PtdIns3P supply for PIKfyve, operating through activated class I PI3Ks.
5	25619930	Our data provide the first evidence that the vacuolation phenotype in Vps34KO podocytes is due to PIKfyve dysfunction and that Vps34 is a main PtdIns3P source for constitutive PIKfyve functionality.
6	25619930	Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of the eight mammalian PI3Ks, is presumed as a main candidate.
7	25619930	To clarify the mechanism of Vps34 KO-triggered vacuolation and the PtdIns3P source for PIKfyve functionality, here we have characterized a podocyte cell type derived from Vps34fl/fl mice, which, upon Cre-mediated gene KO, robustly formed cytoplasmic vacuoles resembling those in PikfyveKO MEFs.
8	25619930	Analyses of phosphoinositide profiles by HPLC and localization patterns by a PtdIns3P biosensor revealed that Vps34 is the main supplier of localized PtdIns3P not only for PIKfyve activity but also for membrane recruitment.
9	25619930	We further revealed a plausible physiologically-relevant Vps34-independent PtdIns3P supply for PIKfyve, operating through activated class I PI3Ks.
10	25619930	Our data provide the first evidence that the vacuolation phenotype in Vps34KO podocytes is due to PIKfyve dysfunction and that Vps34 is a main PtdIns3P source for constitutive PIKfyve functionality.
11	25619930	Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of the eight mammalian PI3Ks, is presumed as a main candidate.
12	25619930	To clarify the mechanism of Vps34 KO-triggered vacuolation and the PtdIns3P source for PIKfyve functionality, here we have characterized a podocyte cell type derived from Vps34fl/fl mice, which, upon Cre-mediated gene KO, robustly formed cytoplasmic vacuoles resembling those in PikfyveKO MEFs.
13	25619930	Analyses of phosphoinositide profiles by HPLC and localization patterns by a PtdIns3P biosensor revealed that Vps34 is the main supplier of localized PtdIns3P not only for PIKfyve activity but also for membrane recruitment.
14	25619930	We further revealed a plausible physiologically-relevant Vps34-independent PtdIns3P supply for PIKfyve, operating through activated class I PI3Ks.
15	25619930	Our data provide the first evidence that the vacuolation phenotype in Vps34KO podocytes is due to PIKfyve dysfunction and that Vps34 is a main PtdIns3P source for constitutive PIKfyve functionality.
16	25619930	Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of the eight mammalian PI3Ks, is presumed as a main candidate.
17	25619930	To clarify the mechanism of Vps34 KO-triggered vacuolation and the PtdIns3P source for PIKfyve functionality, here we have characterized a podocyte cell type derived from Vps34fl/fl mice, which, upon Cre-mediated gene KO, robustly formed cytoplasmic vacuoles resembling those in PikfyveKO MEFs.
18	25619930	Analyses of phosphoinositide profiles by HPLC and localization patterns by a PtdIns3P biosensor revealed that Vps34 is the main supplier of localized PtdIns3P not only for PIKfyve activity but also for membrane recruitment.
19	25619930	We further revealed a plausible physiologically-relevant Vps34-independent PtdIns3P supply for PIKfyve, operating through activated class I PI3Ks.
20	25619930	Our data provide the first evidence that the vacuolation phenotype in Vps34KO podocytes is due to PIKfyve dysfunction and that Vps34 is a main PtdIns3P source for constitutive PIKfyve functionality.
21	26825532	Deletion of a key endosomal trafficking regulator, the class 3 phosphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aberrant endosomal membrane morphology and podocyte dysfunction.
22	26825532	We recently showed that the vacuolation phenotype in cultured Vps34-deficient podocytes is caused by the absence of a substrate for the Vps34 downstream effector PtdIns 3-phosphate 5-kinase (PIKfyve), which phosphorylates Vps34-generated PtdIns(3)P to produce PtdIns (3,5)P2.
23	28216340	Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14^L156R is rescued by starvation and inhibition of vacuolar-ATPase.
24	28216340	One important endolysosomal specific PI is PI(3,5)P₂, generated by the PIKfyve kinase, which orchestrates in combination with Vac14 and Fig4.
25	28216340	Here, we characterize the vacuolization phenotype caused by overexpression of the PIKfyve binding deficient mutant Vac14^L156R in podocytes, which represent specialized cells of the kidney.
26	28216340	Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14^L156R is rescued by starvation and inhibition of vacuolar-ATPase.
27	28216340	One important endolysosomal specific PI is PI(3,5)P₂, generated by the PIKfyve kinase, which orchestrates in combination with Vac14 and Fig4.
28	28216340	Here, we characterize the vacuolization phenotype caused by overexpression of the PIKfyve binding deficient mutant Vac14^L156R in podocytes, which represent specialized cells of the kidney.
29	28216340	Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14^L156R is rescued by starvation and inhibition of vacuolar-ATPase.
30	28216340	One important endolysosomal specific PI is PI(3,5)P₂, generated by the PIKfyve kinase, which orchestrates in combination with Vac14 and Fig4.
31	28216340	Here, we characterize the vacuolization phenotype caused by overexpression of the PIKfyve binding deficient mutant Vac14^L156R in podocytes, which represent specialized cells of the kidney.
32	30066585	This complex, including the scaffold protein Vac14, the lipid kinase PIKfyve, and its counteracting lipid phosphatase Fig4, regulates intracellular phosphatidylinositol phosphate levels, which in turn, control the maturation of early-into-late endosomes, as well as the processing of autophagosomes into autophagolysosomes.
33	30066585	Taken together, our data suggest that increased albuminuria of Vac14^L156R-overexpressing mice is a consequence of a lowered endo- and transcytosis of albumin in renal tubules.