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Gene Information
Gene symbol: PKD1
Gene name: polycystic kidney disease 1 (autosomal dominant)
HGNC ID: 9008
Synonyms: PBP, Pc-1, TRPP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | KIRREL | 1 hits |
| 2 | PKD2 | 1 hits |
| 3 | PRKD1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12660326 | Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. |
| 2 | 12660326 | Nephrin and NEPH1, the gene products of NPHS1 and NEPH1, are podocyte membrane proteins of the Ig superfamily. |
| 3 | 12660326 | Similar to the nephrin knockout, mice lacking NEPH1 show severe proteinuria leading to perinatal death. |
| 4 | 12660326 | This NEPH1-Ig fusion protein labeled the glomerular capillary wall of mouse kidneys in a staining pattern identical to NEPH1 and nephrin, prompting speculation that that NEPH1 might form homodimers and/or heterodimers with nephrin. |
| 5 | 12660326 | Fusion proteins containing two Ig domains of NEPH1 were sufficient to immobilize NEPH1, but they failed to interact with control protein containing the phylogenetically related PKD repeats of polycystin-1. |
| 6 | 12660326 | NEPH1 also precipitated nephrin, a protein with eight Ig domains and a fibronectin-like domain. |
| 7 | 12660326 | Truncational analysis of nephrin revealed a very similar mode of interaction, i.e., two nephrin Ig domains fused to human IgG precipitated either nephrin or NEPH1, but not the control protein. |
| 8 | 12660326 | Both NEPH1 and nephrin interactions were strictly dependent upon posttranslational glycosylation, and bacterially expressed protein failed to bind NEPH1. |
| 9 | 12660326 | These findings demonstrate that the Ig domains of NEPH1 and nephrin form promiscuous homodimeric and heterodimeric interactions that may facilitate cis- and trans- homodimerizations and heterodimerizations of these molecules at the glomerular slit diaphragm. |
| 10 | 21085109 | Polycystin 1 regulates mTOR activity through different pathways, and TSC intersects with the primary cilium, a crucial cell organelle in the pathogenesis of PKD. |
| 11 | 23376035 | Mutations in PKD1 and PKD2, the genes encoding the proteins polycystin-1 (PC1) and polycystin-2 (PC2), cause autosomal dominant polycystic kidney disease (ADPKD). |
| 12 | 26493500 | Knockout of the polycystic kidney disease genes PKD1 or PKD2 induces cyst formation from kidney tubules. |