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Gene Information
Gene symbol: PKN2
Gene name: protein kinase N2
HGNC ID: 9406
Synonyms: PRK2, Pak-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PAK1 | 1 hits |
| 2 | PAK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20071462 | The tyrosine phosphorylation of nephrin is reported to regulate podocyte morphology via the Nck adaptor proteins. |
| 2 | 20071462 | In mouse podocytes, Pak2 was predominantly phosphorylated, concentrated at the tips of the cellular processes, and its expression and/or phosphorylation were further increased when differentiated. |
| 3 | 20071462 | Overexpression of rat nephrin in podocytes increased Pak1/2 phosphorylation, which was abolished when the Nck binding sites were mutated. |
| 4 | 20071462 | Furthermore, dominant-negative Nck constructs blocked the Pak1 phosphorylation induced by antibody-mediated cross linking of nephrin. |
| 5 | 20071462 | Transient transfection of constitutively kinase-active Pak1 into differentiated mouse podocytes decreased stress fibers, increased cortical F-actin, and extended the cellular processes, whereas kinase-dead mutant, kinase inhibitory construct, and Pak2 knockdown by shRNA had the opposite effect. |
| 6 | 20071462 | In a rat model of puromycin aminonucleoside nephrosis, Pak1/2 phosphorylation was decreased in glomeruli, concomitantly with a decrease of nephrin tyrosine phosphorylation. |
| 7 | 20071462 | The tyrosine phosphorylation of nephrin is reported to regulate podocyte morphology via the Nck adaptor proteins. |
| 8 | 20071462 | In mouse podocytes, Pak2 was predominantly phosphorylated, concentrated at the tips of the cellular processes, and its expression and/or phosphorylation were further increased when differentiated. |
| 9 | 20071462 | Overexpression of rat nephrin in podocytes increased Pak1/2 phosphorylation, which was abolished when the Nck binding sites were mutated. |
| 10 | 20071462 | Furthermore, dominant-negative Nck constructs blocked the Pak1 phosphorylation induced by antibody-mediated cross linking of nephrin. |
| 11 | 20071462 | Transient transfection of constitutively kinase-active Pak1 into differentiated mouse podocytes decreased stress fibers, increased cortical F-actin, and extended the cellular processes, whereas kinase-dead mutant, kinase inhibitory construct, and Pak2 knockdown by shRNA had the opposite effect. |
| 12 | 20071462 | In a rat model of puromycin aminonucleoside nephrosis, Pak1/2 phosphorylation was decreased in glomeruli, concomitantly with a decrease of nephrin tyrosine phosphorylation. |