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Gene Information
Gene symbol: PLCD1
Gene name: phospholipase C, delta 1
HGNC ID: 9060
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PLCB1 | 1 hits |
| 2 | SYNJ1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16014575 | Adhesion of rat glomerular epithelial cells (GEC) to collagen activates focal adhesion kinase (FAK) and the Ras-extracellular signal-regulated kinase (ERK) pathway and supports survival (prevents apoptosis). |
| 2 | 16014575 | Parental GEC (adherent to collagen) and GEC stably transfected with constitutively active mutants of mitogen-activated protein kinase kinase (R4F-MEK) or FAK (CD2-FAK) (on plastic) showed ERK activation, low levels of apoptosis, and a cortical distribution of F-actin. |
| 3 | 16014575 | However, disruption of the actin cytoskeleton with cytochalasin D or latrunculin B in parental GEC (on collagen) and in GEC that express R4F-MEK or CD2-FAK (on plastic) decreased ERK activation and increased apoptosis. |
| 4 | 16014575 | Expression of a constitutively active RhoA (L(63)RhoA) induced assembly of cortical F-actin, promoted ERK activation, and supplanted the requirement of collagen for survival. |
| 5 | 16014575 | Downregulation or sequestration of PIP(2) by transfection with an inositol 5'-phosphatase or the plextrin-homology domain of phospholipase C-delta1 decreased F-actin content and survival. |
| 6 | 16014575 | These results demonstrate a reciprocal relationship between collagen-induced cortical F-actin assembly and collagen-dependent survival signaling, including ERK activation. |