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Gene Information
Gene symbol: PLCL1
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTN4 | 1 hits |
| 2 | LAMB2 | 1 hits |
| 3 | NPHS1 | 1 hits |
| 4 | NPHS2 | 1 hits |
| 5 | PLCE1 | 1 hits |
| 6 | TRPC6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17086182 | Using positional cloning, we identified mutations in the phospholipase C epsilon gene (PLCE1) as causing early-onset nephrotic syndrome with end-stage kidney disease. |
| 2 | 19562370 | Here, we describe already well-characterized genetic diseases due to mutations in nephrin, podocin, CD2AP, alpha-actinin-4, WT1, and laminin beta2 chain, as well as more recently identified genetic abnormalities in TRPC6, phospholipase C epsilon, and the proteins encoded by the mitochondrial genome. |
| 3 | 25521631 | Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. |
| 4 | 25521631 | In eukaryotic cells, activation of phospholipase C (PLC)-coupled membrane receptors by hormones leads to an increase in the intracellular Ca(2+) concentration [Ca(2+) ]i . |
| 5 | 25521631 | Catalytic activity of PLCs results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) which opens DAG-sensitive classical transient receptor channels 3, 6, and 7 (TRPC3/6/7), initiating Ca(2+) influx from the extracellular space. |
| 6 | 25521631 | PLCε-/- podocytes however, were undistinguishable from WT podocytes in their angiotensin II-induced formation of actin stress fibers and their GTPγS-induced TRPC6 activation, pointing to a redundant role of PLCε-mediated TRPC6 activation at least in podocytes. |
| 7 | 32238860 | PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic syndrome. |
| 8 | 32238860 | PLCE1 colocalized with Rho GTPases in glomeruli. |
| 9 | 32238860 | Knockdown or knockout of PLCE1 in podocytes resulted in decreased levels of GTP-bound Rac1 and Cdc42, but not those of RhoA, and caused a reduction in cell migration. |
| 10 | 32238860 | Similar to the PLCE1 knockout, NCK2 knockout resulted in decreased podocyte migration. |
| 11 | 32238860 | Knockout of PLCE1 reduced the EGF-induced activation of ERK and cell proliferation in podocytes, whereas knockout of NCK2 did not affect proliferation. |
| 12 | 32238860 | Further, the knockout of PLCE1 also resulted in decreased expression of podocyte markers, including NEPH1, NPHS1, WT1, and SYNPO, upon differentiation, but the knockout of NCK2 did not affect the expression of these markers. |
| 13 | 32238860 | Therefore, our findings demonstrate that PLCE1 regulates Rho GTPase activity and cell migration through interacting with NCK2 and that PLCE1 also plays a role in the proliferation and differentiation of podocytes, regardless of the presence of NCK2. |