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Gene Information

Gene symbol: POMC

Gene name: proopiomelanocortin

HGNC ID: 9201

Synonyms: MSH, POC, CLIP, ACTH, NPP, LPH

Related Genes

#	Gene Symbol	Number of hits
1	MC1R	1 hits

Related Sentences

#	PMID	Sentence
1	27270328	Despite prior corticosteroid resistance, all patients responded to ACTH monotherapy and ultimately achieved clinical remission, inferring a steroidogenic-independent and MC1R-dispensable anti-proteinuric effect of melanocortin signaling.
2	26887829	Melanocortin 1 receptor agonist protects podocytes through catalase and RhoA activation.
3	26887829	We have previously shown that adrenocorticotropic hormone and a selective agonist for the melanocortin 1 receptor (MC1R) exert beneficial actions in experimental membranous nephropathy with reduced proteinuria, reduced oxidative stress, and improved glomerular morphology and function.
4	26887829	We showed that puromycin promotes MC1R expression in podocytes and that activation of MC1R promotes an increase of catalase activity and reduces oxidative stress, which results in the dephosphorylation of p190RhoGAP and formation of stress fibers through RhoA.
5	24498203	We have previously reported that ACTH may act directly on podocytes through the melanocortin 1 receptor (MC1R).
6	20507942	Podocytes expressed most MC1R protein, which colocalized with synaptopodin but not with an endothelial-specific lectin.
7	20507942	These data may explain the proteinuria-reducing effects of ACTH observed in patients with membranous nephropathy, and MC1R agonists may provide a new therapeutic option for these patients.