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Gene Information
Gene symbol: POU5F1
Gene name: POU class 5 homeobox 1
HGNC ID: 9221
Synonyms: OCT3, Oct4, MGC22487
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALPI | 1 hits |
| 2 | CTNNB1 | 1 hits |
| 3 | HSP90B1 | 1 hits |
| 4 | JUP | 1 hits |
| 5 | KLF4 | 1 hits |
| 6 | MYC | 1 hits |
| 7 | NPHS1 | 1 hits |
| 8 | NPHS2 | 1 hits |
| 9 | NR2C2AP | 1 hits |
| 10 | PAX2 | 1 hits |
| 11 | SOX2 | 1 hits |
| 12 | SYNPO | 1 hits |
| 13 | WT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 30222766 | Conditionally immortalized human podocytes served as reference controls. iPSC-derived podocyte-like cells showed a typical podocyte-specific morphology and distinct expression of podocyte markers synaptopodin, podocin, nephrin and WT-1 after 10 days of differentiation as assessed by immunofluorescence staining or Western blot analysis. qPCR results showed a downregulation of pluripotency markers Oct4 and Sox-2 and a 9-fold upregulation of the podocyte marker synaptopodin during the time course of differentiation. |
| 2 | 27588086 | In addition, the expression of octamer-binding transcription factor 4 (Oct-4), a stem cell marker, was detected and suggested that kidney-specific stem cells were present in the DT-treated tissue samples. |
| 3 | 27588086 | The unique cells were positive for Oct-4 and Pax-2; thus suggesting that the identified cells were kidney-derived stem cells. |
| 4 | 25460740 | Moreover, the effects of the HO-system on podocyte cytoskeletal proteins like podocin, podocalyxin, CD2-associated-protein (CD2AP) and proteins of regeneration/repair like beta-catenin, Oct3/4, WT1 and Pax2 in renal tissue from normoglycemic obese Zucker-fatty rats (ZFs) have not been reported. |
| 5 | 25460740 | These were associated with enhanced expression of beta-catenin, Oct3/4, WT1, Pax2 and nephrin, an essential transmembrane protein required for the formation of the scaffoldings of the podocyte slit-diaphragm, permitting the filtration of small ions, but not massive excretion of proteins, hence proteinuria. |
| 6 | 25460740 | Besides nephrin, hemin also enhanced other important podocyte-regulators including, podocalyxin, podocin and CD2AP. |
| 7 | 25460740 | Collectively, these data suggest that hemin ameliorates nephropathy by potentiating the expression of proteins of repair/regeneration, abating oxidative/inflammatory mediators, reducing renal histo-pathological lesions, while enhancing nephrin, podocin, podocalyxin, CD2AP and creatinine clearance, with corresponding reduction of albuminuria/proteinuria suggesting improved renal function in hemin-treated ZFs. |
| 8 | 21566060 | Here, we reprogrammed normal human mesangial cells to pluripotency by retroviral transduction using defined factors (OCT4, SOX2, KLF4 and c-Myc). |
| 9 | 21566060 | Here, we reprogrammed normal human mesangial cells to pluripotency by retroviral transduction using defined factors (OCT4, SOX2, KLF4 and c-Myc). |
| 10 | 21566060 | The kidney iPS (kiPS) cells resembled human embryonic stem-cell-like colonies in morphology and gene expression: They were alkaline phosphatase-positive; expressed OCT3/4, TRA-1 to 60 and TRA-1 to 81 proteins; and showed downregulation of mesangial cell markers. |
| 11 | 21566060 | The kidney iPS (kiPS) cells resembled human embryonic stem-cell-like colonies in morphology and gene expression: They were alkaline phosphatase-positive; expressed OCT3/4, TRA-1 to 60 and TRA-1 to 81 proteins; and showed downregulation of mesangial cell markers. |