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PMID |
Sentence |
1 |
9121603
|
The first receptor which has been cloned and well characterized is "PTH/PTHrP receptor-1".
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2 |
9121603
|
It is activated not only by PTH, but also by PTH-related peptide (PTHrP), via a signal transduction system involving G-proteins, adenylate cyclase and phospholipase C.
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3 |
9121603
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One or several receptors are probably expressed in the keratinocyte and the glomerular podocyte which are not identical with PTH/ PTHrP receptor-1.
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4 |
9121603
|
A third receptor, which has been cloned recently and called "PTH2 receptor", recognizes solely PTH.
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5 |
9121603
|
There is also evidence for a fourth receptor, called "C-PTH receptor", recognizing C-terminal PTH fragments which are generally considered to be biologically inactive.
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6 |
9121603
|
Down-regulation of PTH/PTHrP receptor-1 mRNA expression could explain the well-known resistance to the action of PTH in chronic renal failure.
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7 |
9121603
|
A mutation of PTH/PTHrP receptor-1 causes Jansen-type metaphyseal chondrodysplasia.
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8 |
9121603
|
However, no alteration of the PTH/PTHrP receptor-1 gene structure has been found in type 1b pseudohypoparathyroidism.
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