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Gene Information
Gene symbol: PTPN11
Gene name: protein tyrosine phosphatase, non-receptor type 11
HGNC ID: 9644
Synonyms: BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NPHS1 | 1 hits |
| 2 | PTPN6 | 1 hits |
| 3 | SIRPA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28352079 | In addition, renal mRNA and serum concentrations of inflammatory cytokines IL-1β, TNFα, INFγ and IL-12 p70 were significantly decreased in LPS-treated knockout mice compared with controls. |
| 2 | 28352079 | Moreover, the protective effects of podocyte Shp2 deficiency were associated with decreased LPS-induced NF-κB and MAPK activation, nephrin phosphorylation and attenuated endoplasmic reticulum stress. |
| 3 | 26644409 | Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury. |
| 4 | 26644409 | Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury. |
| 5 | 26644409 | We observed an increase in nephrin tyrosine phosphorylation in the presence of Shp2 in cell culture studies. |
| 6 | 26644409 | We observed an increase in nephrin tyrosine phosphorylation in the presence of Shp2 in cell culture studies. |
| 7 | 23842779 | Signal-regulatory protein-α (SIRPα) is a transmembrane protein that contains tyrosine phosphorylation sites in its cytoplasmic region; two tyrosine phosphatases, SHP-1 and SHP-2, bind to these sites in a phosphorylation-dependent manner and transduce multiple intracellular signals. |