Ignet

Gene Information

Gene symbol: RAG2

Gene name: recombination activating gene 2

HGNC ID: 9832

Related Genes

#	Gene Symbol	Number of hits
1	CDA	1 hits
2	IL15	1 hits
3	IL2	1 hits
4	IL2RA	1 hits
5	IL2RB	1 hits
6	IL2RG	1 hits
7	IL9	1 hits
8	REN	1 hits

Related Sentences

#	PMID	Sentence
1	28111009	Anti-GBM-GN was induced in three strains of immune-deficient mice (Rag2^-/-, Rag2^-/-Il2rg^-/-, and Rag2^-/-Il2rb^-/-) that are devoid of either T/B cells or T/B/NK cells.
2	28111009	The Rag2^-/-Il2rg^-/- or Rag2^-/-Il2rb^-/- mice harbor an additional deletion of either the common gamma chain (γC) or the interleukin-2 receptor β subunit (IL-2Rβ), respectively, impairing IL-15 signaling in particular.
3	28111009	Given that IL-15 has been found highly expressed in nephritic kidneys despite the absence of lymphocytes, we then studied this cytokine in vitro on primary cultured podocytes from immune-deficient mice (Rag2^-/-Il2rg^-/- and Rag2^-/-Il2rb^-/-) compared to controls.
4	28111009	IL-15 induced downstream activation of JAK1/3 and SYK in primary cultured podocytes.
5	28111009	IL-15-dependent JAK/SYK induction was impaired in the absence of γC or IL-2Rβ.
6	28111009	Anti-GBM-GN was induced in three strains of immune-deficient mice (Rag2^-/-, Rag2^-/-Il2rg^-/-, and Rag2^-/-Il2rb^-/-) that are devoid of either T/B cells or T/B/NK cells.
7	28111009	The Rag2^-/-Il2rg^-/- or Rag2^-/-Il2rb^-/- mice harbor an additional deletion of either the common gamma chain (γC) or the interleukin-2 receptor β subunit (IL-2Rβ), respectively, impairing IL-15 signaling in particular.
8	28111009	Given that IL-15 has been found highly expressed in nephritic kidneys despite the absence of lymphocytes, we then studied this cytokine in vitro on primary cultured podocytes from immune-deficient mice (Rag2^-/-Il2rg^-/- and Rag2^-/-Il2rb^-/-) compared to controls.
9	28111009	IL-15 induced downstream activation of JAK1/3 and SYK in primary cultured podocytes.
10	28111009	IL-15-dependent JAK/SYK induction was impaired in the absence of γC or IL-2Rβ.
11	28111009	Anti-GBM-GN was induced in three strains of immune-deficient mice (Rag2^-/-, Rag2^-/-Il2rg^-/-, and Rag2^-/-Il2rb^-/-) that are devoid of either T/B cells or T/B/NK cells.
12	28111009	The Rag2^-/-Il2rg^-/- or Rag2^-/-Il2rb^-/- mice harbor an additional deletion of either the common gamma chain (γC) or the interleukin-2 receptor β subunit (IL-2Rβ), respectively, impairing IL-15 signaling in particular.
13	28111009	Given that IL-15 has been found highly expressed in nephritic kidneys despite the absence of lymphocytes, we then studied this cytokine in vitro on primary cultured podocytes from immune-deficient mice (Rag2^-/-Il2rg^-/- and Rag2^-/-Il2rb^-/-) compared to controls.
14	28111009	IL-15 induced downstream activation of JAK1/3 and SYK in primary cultured podocytes.
15	28111009	IL-15-dependent JAK/SYK induction was impaired in the absence of γC or IL-2Rβ.
16	29512722	Furthermore, the present study investigated the mechanism underlying IgG production in these cells by examining the expression of recombination activating gene (RAG)1, RAG2 and activation‑induced cytidine deaminase.
17	32446933	However, selective deficiency of IL-9 in the innate immune system in Il9^-/-Rag2^-/- mice that lack T and B cells did not alter the outcome of AN, indicating that IL-9 derived from the adaptive immune system was the major driver of tissue protection in this model.
18	32918942	We examined the presence of various components of the renin-angiotensin system such as angiotensin II receptors, angiotensinogen, and angiotensin-converting enzymes 1 and 2.
19	32918942	Renin production by the organoids was responsive to regulation by parathyroid hormone.
20	32918942	Subcutaneously implanted kidney organoids in immunodeficient IL2Ry^-/-Rag2^-/- mice were successfully vascularized, maintained tubular and glomerular structures, and retained capacity to produce renin two months after implantation.