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Gene Information
Gene symbol: RELB
Gene name: v-rel reticuloendotheliosis viral oncogene homolog B
HGNC ID: 9956
Synonyms: REL-B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL19 | 1 hits |
| 2 | CCL2 | 1 hits |
| 3 | CCL21 | 1 hits |
| 4 | CCL5 | 1 hits |
| 5 | CD40 | 1 hits |
| 6 | MAP3K14 | 1 hits |
| 7 | NFKB1 | 1 hits |
| 8 | NFKB2 | 1 hits |
| 9 | PSIP1 | 1 hits |
| 10 | REL | 1 hits |
| 11 | RELA | 1 hits |
| 12 | TNFSF12 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16204413 | Although podocytes produce p50, p52, RelA, RelB, and c-Rel, electrophoretic mobility shift assays and immunocytochemistry showed a predominant nuclear accumulation of p50/RelA-containing NF-kappaB dimers in HIV-1-expressing podocytes compared with normal. |
| 2 | 16204413 | The mechanism of NF-kappaB activation involved increased phosphorylation of IkappaBalpha, resulting in an enhanced turnover of the IkappaBalpha protein. |
| 3 | 20953353 | Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. |
| 4 | 20953353 | TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. |
| 5 | 20953353 | TRAIL activates NF-kappaB in tubular cells and promotes apoptosis in tubular cells and podocytes, especially in a high-glucose environment. |
| 6 | 20953353 | By contrast, osteoprotegerin plays a protective role against TRAIL-induced apoptosis. |
| 7 | 20953353 | Another family member, TNF-like weak inducer of apoptosis (TWEAK induces inflammation and tubular cell death or proliferation, depending on the microenvironment. |
| 8 | 20953353 | While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses. |
| 9 | 20953353 | TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. |