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Gene Information
Gene symbol: SCAP
Gene name: SREBF chaperone
HGNC ID: 30634
Synonyms: KIAA0199
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CNBP | 1 hits |
| 2 | LDLR | 1 hits |
| 3 | PCSK9 | 1 hits |
| 4 | SREBF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25921580 | Additionally, lipid accumulation in the kidneys of db/db mice was increased due to increased protein expressions of LDLr, sterol regulatory element-binding protein (SREBP) cleavage-activating protein, and SREBP-2. |
| 2 | 27019638 | To maintain a cholesterol homeostasis, LDLR expression is tightly regulated by sterol regulatory element-binding protein-2 (SREBP-2) and SREBP cleavage-activating protein (SCAP) in transcriptional level and by proprotein convertase subtilisin/kexin type 9 (PCSK9) in posttranscriptional level. |
| 3 | 27019638 | It has been demonstrated that inflammation, renin-angiotensin system (RAS) activation, and hyperglycemia induce the disruption of LDLR pathway, which might contribute to lipid disorder-mediated organ injury (atherosclerosis, non-alcoholic fatty liver disease, kidney fibrosis, etc). |