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Gene Information
Gene symbol: SCD
Gene name: stearoyl-CoA desaturase (delta-9-desaturase)
HGNC ID: 10571
Synonyms: FADS5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOL1 | 1 hits |
| 2 | DGAT1 | 1 hits |
| 3 | MLXIPL | 1 hits |
| 4 | NR1H3 | 1 hits |
| 5 | PKLR | 1 hits |
| 6 | SCD5 | 1 hits |
| 7 | SLC5A2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23867797 | Functionally, the liver X receptor agonists TO901317 and GW3965, two known inducers of SCD, increased Scd-1 and Scd-2 expression in cultured podocytes and reduced palmitic acid-induced cell death. |
| 2 | 26147622 | In sickle cell disease (SCD) patients, we reported previously a genetic interaction between APOL1 and MYH9. |
| 3 | 26147622 | Furthermore, concordant with the genetic interaction observed in SCD patients, APOL1 G2 reduces myh9 expression in vivo, suggesting a possible interaction between the altered APOL1 and myh9. |
| 4 | 28196866 | We found that SGLT2 inhibition caused marked decreases in systolic blood pressure, kidney weight/body weight ratio, urinary albumin, and urinary thiobarbituric acid-reacting substances. |
| 5 | 28196866 | SGLT2 inhibition prevented renal lipid accumulation via inhibition of carbohydrate-responsive element-binding protein-β, pyruvate kinase L, SCD-1, and DGAT1, key transcriptional factors and enzymes that mediate fatty acid and triglyceride synthesis. |
| 6 | 28196866 | SGLT2 inhibition also prevented inflammation via inhibition of CD68 macrophage accumulation and expression of p65, TLR4, MCP-1, and osteopontin. |
| 7 | 28196866 | These effects were associated with reduced mesangial expansion, accumulation of the extracellular matrix proteins fibronectin and type IV collagen, and loss of podocyte markers WT1 and synaptopodin, as determined by immunofluorescence microscopy. |